ATS 2019 Virtual Final Program

11:00 Whole Genome Sequencing of Nontuberculous Mycobacterium (NTM) Derived from Sputum Specimen in Co-Habiting Patients with NTM Pulmonary Disease/ J.K. Yoon, T.S. Kim, J. Kim, J.-J. Yim, Seoul, Korea, Republic of, p.A1038 BASIC • CLINICAL • TRANSLATIONAL MINI SYMPOSIUM A19 LESS IDIOPATHIC: STRUCTURAL AND FUNCTIONAL ABNORMALITIES IN IPF 9:15 a.m. - 11:15 a.m. KBHCCD Room D220/D227 (Level 2) Chairing: A. Stewart, PhD, Melbourne, Australia S. Dua, MD, New York, NY F. Xu, PhD, Vancouver, Canada Oral Presentations 9:15 A Comparison of Normal Lung Anatomy to Minimal to Established Fibrosis in Idiopathic Pulmonary Fibrosis/ F. Xu, N. Tanabe, J.E. McDonough, D.M. Vasilescu, K. Ikezoe, D. Kinose, K. Ng, S. Verleden, B. Vanaudenaerde, J. Verschakelen, J.D. Cooper, M.E. Lenburg, A. Spira, R. Ng, J.C. Hogg, Vancouver, Canada, p.A1039 9:30 Normalized Vessel Volume from Quantitative Computed Tomography Predicts Survival in Idiopathic Pulmonary Fibrosis/ J. Jacob, M. Pienn, C. Payer, M. Urschler, M. Kokosi, A. Devaraj, A.U. Wells, H. Olschewski, London, United Kingdom, p.A1040 9:45 Prediction of Progression Using Quantum Particle Swarm Optimization and Its Metrics at Single Time Point HRCT Scan in Subjects with IPF/ G.H. Kim, Y. Shi, W.K. Wong, M. Brown, P.Y. Teng, J. Goldin, Los Angeles, CA, p.A1041 10:00 Human Lung Bacterial Communities Associated with Clinical Outcome in Patients with Idiopathic Pulmonary Fibrosis/ H. Yoon, J.W. Song, K. Choi, H.-S. Kim, J.-H. Kim, W. Kim, D.S. Kim, Seoul, Korea, Republic of, p.A1042 10:15 Stiffness: A ‘Master Regulator’ of Human Lung Fibroblast Phenotypic Plasticity?/ A. Stewart, T. Harris, F. Jativa, J. Jaffar, P.V.S. Lee, G. Westall, M. Wilson, A. Berhan, Melbourne, Australia, p.A1043 10:30 The Jamming Transition Is Dynamically and Structurally Delayed in Idiopathic Pulmonary Fibrosis Bronchial Epithelial/ I.T. Stancil, E. Dobrinskikh, J.E. Michalski, I.V. Yang, B.J. Smith, D.A. Schwartz, Aurora, CO, p.A1044 10:45 Role of Terra on Telomeric and Mitochondrial Functions in IPF Pathogenesis/ G. Yu, J. Yang, W. Zhao, G. Iberra, X. Chen, X. Guo, N. Kaminski, Xinxiang, China, p.A1045 11:00 Characterization of GLPG1205 in Mouse Fibrosis Models: A Potent and Selective Antagonist of GPR84 for Treatment of Idiopathic Pulmonary Fibrosis/ L. Saniere, F. Marsais, C. Jagerschmidt, S. Meurisse, S. Cuzic, K. Shoji, P. Clement-Lacroix, N. Van Osselaer, S. De Vos, Romainville, France, p.A1046 BASIC • TRANSLATIONAL RAPID: RAPID ABSTRACT POSTER DISCUSSION SESSION A21 ADVANCES IN ASTHMA PATHOGENESIS 9:15 a.m. - 11:15 a.m. KBHCCD Room D222-D224 (Level 2) Abstract Summaries 9:15-9:45 Viewing/Discussion 9:45-11:15 Chairing: R.A. Rahimi, MD, PhD, Boston, MA B. Lambrecht, MD, Ghent, Belgium A.I. Sperling, PhD, ATSF, Chicago, IL 501 Reciprocal Fungal and Bacterial Microbiota in Airways of Patients with T2-High Associated Asthma/ A. Sharma, B. Laxman, E.T. Naureckas, D.K. Hogarth, A.I. Sperling, J. Solway, C. Ober, J. Gilbert, S.R. White, Chicago, IL, p.A1047 502 S-Glutathionylation of Pyruvate Kinase M2 Is Associated with Metabolic Reprogramming and Cytokine Production in the Development of Allergic Obese Airway Disease/ A. Manuel, X. Qian, C. van de Wetering, S.B. Chia, R. Aboushousha, J. van der Velden, A.E. Dixon, M. Poynter, Y.-W. Lam, C.G. Irvin, Y.M.W. Janssen-Heininger, Burlington, VT, p.A1048 503 The Cytosolic DNA Sensor Cyclic-GMP-AMP Synthase Is Critical in Experimental Models of Allergic Airway Inflammation/ F. Yan, Y. Han, L. Chen, H. Liu, Hangzhou, China, p.A1049 504 Toll-Interacting Protein (Tollip) Inhibits ST2 Signaling in Airways Exposed to Type 2 Cytokines and Rhinovirus/ H.W. Chu, R. Al Mubarak, N. Pavelka, D.R. Voelker, M.A. Seibold, J.G. Ledford, M. Kraft, L. Li, A. Dakhama, Denver, CO, p.A1050 505 Axl Receptor Tyrosine Kinase Is Decreased in Severe Asthma and Suppresses Eosinophilic Airway Inflammation in an Allergen-Induced Asthma Model/ K. Itakura, N. Fujino, M. Yamada, Y. Kamide, I. Saito, H. Sugiura, M. Taniguchi, M. Ichinose, Sendai, Japan, p.A1051 506 Club Cell Secretory Protein-16 Deficiency Leads to an Eosinophilic and Neutrophilic Airway Inflammation in Response to House Dust Mite in a Mouse Model of Asthma/ J. Gozdz, D. Francisco, A. Manne, M. Conway, F.D. Martinez, S. Guerra, J.G. Ledford, M. Kraft, Tucson, AZ, p.A1052 507 Hsp70 Is a Positive Regulator of Airway Inflammation and Mucus Hypersecretion Through the Increase of Type 2 Cytokine Production by Activated T Cells in Allergic Asthma/ D.J.K. Yombo, M.M. Mentik-Kane, M.S. Wilson, T.A. Wynn, S.K. Madala, Cincinnati, OH, p.A1053 508 Negative Human IL33 Regulation in Lung Endothelium During Allergic Inflammation Is Dependent on a 5kB Upstream Region in the IL33 Locus/ C. Howard, D.C. Decker, K.M. Blaine, I.A. Swanson, D.F. Camacho, M. Nobrega, A.I. Sperling, Chicago, IL, p.A1054 509 Autophagy Limits 15LO1-Mediated Ferroptotic Cell Death and Associated Mitochondrial DNA Release in Human Airway Epithelial Cells (HAECs)/ Y. Deng, T. Nagasaki, Z. Li, N. Bonfiglio, J.B. Trudeau, J. Zhao, S.E. Wenzel, Pittsburgh, PA, p.A1055 ATS 2019 • Dallas, TX 34 SUNDAY • MAY 19