ATS 2019 Virtual Final Program

P823 Validation of a Novel ProteaseTag ® Activity-Based Immunoassay for Quantification of Proteinase 3 in Sputum Sol Samples/ T. Ferguson, K.L. Moffitt, D. Ramsay, C. Robb, D. McCafferty, A. Kennedy, K. DiPetrillo, B. Walker, Belfast, United Kingdom, p.A4532 P824 The Role of Alpha 7 Nicotinic Receptor on Lung Alterations in an Experimental Model of Emphysema Induced by Elastase/ R.S. Banzato, F.P.R. Santana, C.R. Olivo, F.D.Q.S. Lopes, I.F.L.C. Tiberio, M.A.M. Prado, V.F. Prado, C.M. Prado, Sao Paulo, Brazil, p.A4533 P825 Molecular Characterization of A Human LPS Challenge Model/ F. Heissig, T. Litzenburger, M. Müller, K. Wetzel, K. Hohl, R. Schmid, W. Seibold, M. Sarno, A. Gupta, P. Badorrek, C. Faulenbach, J.M. Hohlfeld, Biberach an der Riss, Germany, p.A4534 P826 Sputum Analysis by Chipcytometry Following LPS Inhalation Challenge/ S. Carstensen, O. Holz, M. Müller, J.M. Hohlfeld, Hanover, Germany, p.A4535 P827 The Association Between Ratio of Innate Lymphoid Cell 1 (ILC1) to ILC2 and Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)/ H. Zhu, H. Ge, Y. Zheng, L. Pan, J. Long, Shanghai, China, p.A4536 P828 The Role of Neutrophils Phenotype in Chronic Obstructive Pulmonary Disease/ H. Zhu, H. Ge, L. Pan, J. Long, Y. Zheng, Shanghai, China, p.A4537 P829 The Development of a Novel Immunoassay for the Detection and Quantification of Murine Neutrophil Elastase/ D. McCafferty, A. Kennedy, K.L. Moffitt, C. Robb, T. Ferguson, B. Walker, Belfast, United Kingdom, p.A4538 P830 The Inflammatory Profile of Human Lung Explant Tissue in Response to Smoke Exposure from Biomass Burning/ B. Kc, P.S. Mahapatra, D. Thakker, A. Henry, C.K. Billington, S.P. Puppala, I. Sayers, B.P. Shrestha, I.P. Hall, Nottingham, United Kingdom, p.A4539 P831 Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists/ H. Salvator, S. Grassin-Delyle, N. Mantov, C. Abrial, M. Brollo, C. Faisy, E. Naline, L.-J. Couderc, P. Devillier, Suresnes, France, p.A4540 P832 Sputum Processing with Dithiothreitol interferes with the Detection of Active Proteases/ K.L. Moffitt, C. Robb, A. Kennedy, D. Ramsay, B. Walker, Belfast, United Kingdom, p.A4541 P833 Seasonal Pattern of COPD Exacerbations in the DYNAGITO Trial/ C.R. Jenkins, P.M.A. Calverley, A. Anzueto, A. de la Hoz, F. Voss, K.F. Rabe, J.A. Wedzicha, Sydney, Australia, p.A4542 Facilitator : A. Gaggar, MD, PhD, Birmingham, AL P834 Vanadium Pentoxide Stimulate Inflammatory Response and Autophagy Via Activating ERK Pathway/ S.-H. Lin, C.-H. Lin, Y.-R. Li, H.-H. Chang, Y.-Y. Ching, Changhua, Taiwan, p.A4543 P835 Alpha-1-Antitrypsin Binds to Glucocorticoid Receptor to Induce Angiopoietin-Like Protein 4 Expression/ E.D. Chan, A. Bai, Z. Feng, V. Kadiyala, S. Aerts, J.R. Honda, L. Li, M. Tomasicchio, R. Harbeck, R.A. Sandhaus, A.N. Gerber, X. Bai, Denver, CO, p.A4544 P836 High Dimensional Analysis of NK Cells in Smokers and COPD: Associations of NK Cell Phenotype with Exacerbations/ M.T. Borchers, A. Osterburg, R.J. Panos, Cincinnati, OH, p.A4545 P837 Perforin Inhibition Blocks NK-Mediated In Vitro Killing of Human Lung Epithelial Cells in COPD/ M. Morcos, V.R. Stolberg, M.E. Bates, M.R. Kady, L. McCloskey, J.L. Curtis, C.M. Freeman, Ann Arbor, MI, p.A4546 P838 TLR2 Limits Exaggerated Rhinovirus-Stimulated Type I and III Interferons in COPD Airway Epithelial Cells Via SIRT-1/ H. Reddyvari, N. Xander, W. Li, U. Sajjan, Philadelphia, PA, p.A4547 P839 Variant and Potentially Pathogenic Stem Cells in COPD Lung/ W. Xian, W. Rao, F. Mckeon, Houston, TX, p.A4548 P840 Genetic Overlap of Chronic Obstructive Pulmonary Disease and Cardiovascular Diseases: A Large-Scale Genome-Wide Cross-Trait Analysis/ Z. Zhu, X. Wang, X. Li, Y. Lin, C. Liu, B.D. Hobbs, K. Hasegawa, L. Liang, H.M. Boezen, C.A. Camargo, M.H. Cho, D.C. Christiani, Boston, MA, p.A4549 P841 No Genetic Associations Were Identified with Mepolizumab Efficacy in Eosinophilic COPD/ L. Condreay, C. Gao, E. Bradford, S. Yancey, S. Ghosh, Research Triangle Park, NC, p.A4550 P842 Autoantigen Array Reveals Decreased Expression of Autoantibodies in Sputum of Patients with Chronic Obstructive Pulmonary Disease/ S. Cass, A. Dvorkin-Gheva, J. McGrath, D. Thayaparan, M. Mukherjee, L. Quan-Zhen, P.K. Nair, C. Stevenson, M.R. Stampfli, Hamilton, Canada, p.A4551 P843 Gene Expression-by-Environment Interaction for COPD Phenotypes: Results from a Novel Method/ M. Seo, D. Qiao, S. Lee, R. Chase, J.H. Yun, P. Castaldi, C.P. Hersh, Boston, MA, p.A4552 P844 Effect of Short-Term Oral Prednisone Therapy on Blood Gene Expression/ H. Takiguchi, V.Y. Chen, M. Obeidat, Z. Hollander, J.M. FitzGerald, B.M. McManus, N. Raymond, D.D. Sin, Vancouver, Canada, p.A4553 P845 Lung Function and Gene Expression of Pathogen Recognition Pathway Receptors: A CARDIA Lung Study/ R. Ramasubramanian, R. Kalhan, D. Jacobs, G.R. Washko, L. Hou, M.D. Gross, W. Guan, B. Thyagarajan, Minneapolis, MN, p.A4554 P846 Gene Expression Signature of Asthma COPD Overlap/ A. Saferali, J.H. Yun, S. Lee, R. Chase, P. Castaldi, C.P. Hersh, Boston, MA, p.A4555 P847 Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome in a University Outpatient Pulmonary Practice/ B. Li, A.T. Scardella, Spotswood, NJ, p.A4556 ATS 2019 • Dallas, TX 242 TUESDAY • MAY 21