ATS 2019 Virtual Final Program

P260 Compartmental Gene Expression Analysis in Pulmonary Sarcoidosis/ Y. Huang, C. Ascoli, B. Turturice, C. Schott, P.W. Finn, D.L. Perkins, Chicago, IL, p.A4512 P261 Classification of Potentially Causal Variants in African American Sarcoidosis Using Whole-Genome Sequencing/ N. Pezant, L. Garman, K.A. White, A.M. Levin, M.C. Iannuzzi, B.A. Rybicki, L. Long, C. Montgomery, Oklahoma City, OK, p.A4513 P262 Deep Sequencing of ANXA11 Reveals Ethnicity-Specific Genetic Variants Associated with Sarcoidosis in African Americans/ K.A. White, A. Voth, N. Pezant, L. Garman, A.M. Levin, M.C. Iannuzzi, B. Rybicki, L. Long, C. Montgomery, Oklahoma City, OK, p.A4514 P263 Genomic Susceptibility to the Development of Pediatric Interstitial Lung Disease/ P.C. Cheng, D. Li, S.B. Goldfarb, H. Hakonarson, Philadelphia, PA, p.A4515 BASIC • CLINICAL • TRANSLATIONAL THEMATIC POSTER SESSION C32 COPD: TRANSLATIONAL AND MECHANISTIC STUDIES 9:15 a.m. - 4:15 p.m. KBHCCD Area F (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. Facilitator : B.T. Suratt, MD, Burlington, VT P807 Short-Term Cigarette Smoke Exposure Aggravates Inflammatory Cytokines Releasing, Oxidative Stress and Fibrosis Formation Induced by Lipopolysaccharides/ X. Yu, Z.Y. Liang, L. Fan, Y.B. Chen, L. Wu, Y.J. Xu, L. Lin, Guangzhou, China, p.A4516 P808 Cigarette Smoke Exposure Reduces Leukemia Inhibitory Factor Levels During Respiratory Syncytial Viral Infection/ J. Poon, M.A. Campos, R.F. Foronjy, S. Nath, G. Gupta, C. Railwah, A.J. Dabo, N. Baumlin, M.A. Salathe, P. Geraghty, Brooklyn, NY, p.A4517 P809 Cigarette Smoke Can Activate Fibroblast Growth Factor Signaling in Vascular Smooth Muscle Cells in the COPD Lung/ S. Krick, J. Garth, S.E. Helton, R. Denson, R. Zaharias, J.M. Wells, J.W. Barnes, Birmingham, AL, p.A4518 P810 Effects of Cigarette Smoke Exposure on Tartrate-Resistant Acid Phosphatase Expression in Murine Lung Tissue/ A. van der Veen, P. Lång, M.H. de Jager, G. Andersson, B.N. Melgert, Groningen, Netherlands, p.A4519 P811 Dysfunctional Macrophage Polarization in a COPD Exacerbation Model of Smoke and Influenza Co-Exposure in Mice/ A. van der Veen, M.H. de Jager, E. Post, L.E.S. De Groot, R. Lutter, B.N. Melgert, Groningen, Netherlands, p.A4520 P812 Cigarette Smoke Extract (CSE) Induces RAGE-Mediated Inflammation Is Associated with Activation of Autophagy in Bronchial Epithelial Cell Line/ C.-H. Lin, Y.-R. Li, H.-H. Chang, Y.-Y. Ching, S.-H. Lin, Changhua, Taiwan, p.A4521 P813 Smoke-Induced Genomic Instability in the Airway Epithelium: Role of IL-17-Mediated Inflammation/ C. Cao, H. Shen, S. Ying, Ningbo, China, p.A4522 P814 Nemiralisib in Patients Experiencing an Acute Exacerbation of COPD: Design of a Double-Blind, Randomized, Placebo-Controlled, Dose-Ranging Phase IIb Study/ W. Fahy, F. Homayoun-Valiani, A. Cahn, J. Robertson, A. Templeton, W. Meeraus, R. Wilson, M. Lowings, M. Marotti, M. Tabberer, S. West, E. Hessel, Uxbridge, United Kingdom, p.A4523 P815 Clinically Important Deterioration Among Patients with Chronic Obstructive Pulmonary Disease (COPD) Treated with Glycopyrrolate Eflow ® Closed System (CS) (nebulized Glycopyrrolate) in Pooled Data from Two Randomized, Double Blind, Placebo-Controlled Studies/ E.M. Kerwin, L. Murray, V. Ganapathy, C. Dembek, K. Rajagopalan, Medford, OR, p.A4524 P816 Glucagon-Like Peptide-1 Receptor (GLP-1R) Signaling Ameliorates Dysfunctional Immunity in COPD Patients/ J. Huang, Shanghai, China, p.A4525 P817 Association of Depressive Symptoms with Systemic Inflammation in Patients with COPD/ H. Strollo, C. Karoleski, N.A. Hanania, R.P. Bowler, S.M. Nouraie, C. Riley, J.M. Bon, F.C. Sciurba, Pittsburgh, PA, p.A4526 P818 Pharmacokinetics of the Extrafine Fixed-Dose Combination of Beclomethasone Dipropionate, Formoterol Fumarate, Glycopyrronium Bromide Delivered Via a Pressurized-Metered Dose Inhaler (pMDI) in Chinese Subjects/ G. Georges, Z. Luo, G. Ciurlia, P. Guller, L. Girardello, F. Mariotti, G. Poli, Cary, NC, p.A4527 P819 Pharmacokinetic/Pharmacodynamic Interactions Between Extrafine Beclomethasone Dipropionate and Formoterol Fumarate Components of a Fixed-Dose Combination for Asthma and COPD/ G. Georges, A. Lucardie, C. Garofalo, C. Beaudot, M. Cella, Cary, NC, p.A4528 Facilitator : C.M. Freeman, PhD, Ann Arbor, MI P820 Efficacy and Safety of CHF6001, A Novel Inhaled PDE4 Inhibitor in COPD: The Pioneer Dose Finding Study/ D. Singh, M.A. Nandeuil, C. Pigeon-Francisco, A. Emirova, D. Santoro, S. Biondaro, G. Cohuet, M. Govoni, S. Petruzzelli, Manchester, United Kingdom, p.A4529 P821 Plasma Cathelicidin Measurements During COPD Exacerbations and Outcomes/ R.M. Burkes, A. Ceppe, J.F. Donohue, C.M. Doerschuk, M.B. Drummond, Chapel Hill, NC, p.A4530 P822 Erythromycin Restores Corticosteroid Sensitivity Induced by CSE Through Inhibition of JNK/C-JUN Pathway/ Z. He, Y. Bin, Y. Liang, J. Zhang, M. Li, X. Zhong, Nanning, China, p.A4531 ATS 2019 • Dallas, TX TUESDAY • MAY 21 241 TUESDAY MORNING