ATS 2019 Virtual Final Program

712 V-Type ATPase Mediates Airway Surface Liquid Acidification in Cultured Pig Small Airway Epithelial Cells/ X. Li, I. Thornell, R. Villacreses Rada, C. Brommel, L. Lu, S. Mather, A. Ehler, P. Karp, M. Welsh, J. Zabner, Iowa City, IA, p.A2573 713 Early CF Lung Disease Is Characterized by a Permanent Gel Muco-Inflammatory Milieu/ C.R. Esther, M.S. Muhlebach, C. Ehre, D.B. Hill, M.C. Wolfgang, K.A. Ramsey, M.R. Markovetz, I.C. Garbarine, M.G. Forest, I.C. Seim, B. Zorn, C.B. Morrison, M.F. Delion, B. Thelin, D. Villalon, J.R. Sabater, L. Turkovic, S.C. Ranganathan, S.M. Stick, R.C. Boucher, Chapel Hill, NC, p.A2574 714 Higher Plasma Concentrations of Angiopoietin-1 and Angiopoietin-1/Angiopoietin-2 in Adults with Cystic Fibrosis Compared to Healthy Age Matched Controls/ P. Bhatraju, K. Hisert, M.L. Aitken, C. Goss, W.C. Liles, W.A. Altemeier, Seattle, WA, p.A2575 715 Fibroblasts from Lung Apices and Bases of Patients with Idiopathic Pulmonary Fibrosis Respond Differently to Pirfenidone and TGF-Beta 1/ J. Jaffar, I. Glaspole, K. Symons, G. Westall, Melbourne, Australia, p.A2576 716 BBT-877, a Potent Autotaxin Inhibitor in Clinical Development to Treat Idiopathic Pulmonary Fibrosis/ G. Lee, S.-U. Kang, J.-H. Ryou, J.-J. Lim, D.-Y. Lee, H.-J. Kwon, G.-H. Ha, Y.-H. Lee, Seongnam, Korea, Republic of, p.A2577 717 Tetrathiomolybdate Treatment Attenuates Bleomycin-Induced Pulmonary Fibrosis in a Large Animal Model/ H.B. Derseh, K.U.E. Perera, V.D.S. Nimanthi, E. Koumoundouros, A. Stent, C.N. Pagel, L. Organ, K. Snibson, Parkville, Australia, p.A2578 718 Mucus Matters: Ferrets Demonstrate Restrictive Lung Physiology, Sustained Fibrosis, Mucociliary Decrement in Airways, and Aberrant Repair Following Bleomycin-Induced Pulmonary Fibrosis/ J.E. Peabody, S.E. Phillips, V.Y. Lin, A.T. Adewale, S. Bodduluri, J.M. Lever, M. Weupe, R.-J. Shei, B.H. Rosen, J.F. Engelhardt, G.J. Tearney, D.A. Schwartz, V.J. Thannickal, S.M. Rowe, Birmingham, AL, p.A2579 719 Development of a Novel Combinatorial Therapy for Cystic Fibrosis/ J.P. Nguyen, M. Bianca, R.D. Huff, N. Tiessen, Y. Kim, V. Hou, M. Heller, M.D. Inman, J.A. Hirota, Hamilton, Canada, p.A2580 720 Protective Effect of 3-Carbamoyl Proxyl Against Bleomycin-Induced Lung Fibrosis/ N. Berkman, M. Assayag, S. Goldstein, A. Samuni, Jerusalem, Israel, p.A2581 721 Acute Airway Acidification Modifies Mucus Secretion and Transport Properties/ L. Reznikov, S.-P. Kuan, Y.S. Liao, J. Dadural, E. Collins, M. Guevara, K. Atanasova, K. Vogt, Gainesville, FL, p.A2582 722 Exposure to Bile Salts Alters the Architecture and Host Defense of the Airway Epithelium/ L. Yonker, M. Wood, N.E. Figuereo, B.P. Hurley, H. Mou, Boston, MA, p.A2583 723 VEGFR1-TK Signaling Induces Bleomycin Pulmonary Fibrosis Formation Through Accumulating of VEGFR1+ Cells/ H. Amano, Y. Matsui, K. Eshima, Y. Ito, M. Shibuya, M. Majima, Sagamihara, Japan, p.A2584 724 Autotaxin Inhibitorsin IPF: Elucidation of a Novel Binding Mode for GLPG1690/ B. Heckmann, R. Blanque, N. Triballeau, N. Desroy, T. Temal, A. Monjardet, B. Hrvacic, R. Brys, T.M. Maher, Romainville, France, p.A2585 BASIC • BEHAVIORAL • CLINICAL • TRANSLATIONAL RAPID: RAPID ABSTRACT POSTER DISCUSSION SESSION A109 SRN: OSA PATHOPHYSIOLOGY AND TREATMENT - MOVING TOWARDS PERSONALIZED MEDICINE 2:15 p.m. - 4:15 p.m. OMNI DALLAS DOWNTOWN Trinity Ballroom 1-3 (Level 3) Abstract Summaries 2:15-2:45 Viewing/Discussion 2:45-4:15 Chairing: R.J. Kimoff, MD, Montreal, Canada A.R. Schwartz, MD, Baltimore, MD 901 REM Rebound Predicts CPAP Compliance in Patients with Obstructive Sleep Apnea/ R.S. Leung, A. Udayashankar, Toronto, Canada, p.A2586 902 Loop Gain in REM Versus Non-REM Sleep Using CPAP Manipulation/ L. Messineo, L. Taranto Montemurro, A. Azarbarzin, M. Marques, N. Calianese, D.P. White, D.A. Wellman, S.A. Sands, Boston, MA, p.A2587 903 Mild Intermittent Hypoxia Increases Loop Gain and the Arousal Threshold in Participants with Obstructive Sleep Apnea/ R. Alex, G. Panza, H. Hakim, H. Pinnamaneni, M.S. Badr, S.A. Sands, B.A. Edwards, J.H. Mateika, Detroit, MI, p.A2588 904 Simplified OSA Phenotyping of Respiratory Events for Predicting Oral Appliance Efficacy/ D. Vena, A. Azarbarzin, B.A. Edwards, R. Radmand, M. Marques, L.T. Taranto-Montemurro, N. Calianese, D. White, S. Landry, S.A. Joosten, G. Hamilton, L. Thomson, S.A. Sands, D.A. Wellman, Boston, MA, p.A2589 905 Impact of Oral Appliances on the Pharyngeal Closing Pressure in Patients with Obstructive Sleep Apnea/ G. Garcia, D.A. Campbell, R.S. Bailey, C.M. Welzig, B.T. Woodson, Milwaukee, WI, p.A2590 906 The Value of Awake Nasopharyngoscopy with Müller’s Maneuver in the Prediction of Response to Mandibular Advancement Device Treatment/ E. Van de Perck, S. Op de Beeck, M. Dieltjens, A.E. Verbruggen, A.V. Vroegop, M. Willemen, J. Verbraecken, P.H. Van de Heyning, M.J. Braem, O.M. Vanderveken, Edegem, Belgium, p.A2591 907 Mechanisms Underlying Increased Hypoxic Burden in Patients with Sleep Apnea/ A. Azarbarzin, S.A. Sands, K.L. Stone, L.T. Taranto-Montemurro, D. Vena, K. Yaffe, R. Wang, D.P. White, A. Wellman, S. Redline, Boston, MA, p.A2592 908 A Cross-Over Trial of Postural Therapy for Sleep Disordered Breathing in Native Highlanders/ L.V. Pham, D. Goodman, T. Aguilar, V.Y. Polotsky, W. Checkley, A.R. Schwartz, Baltimore, MD, p.A2593 ATS 2019 • Dallas, TX 116 SUNDAY • MAY 19