ATS 2019 Virtual Final Program

2:15 Of Scars and Mysteries R.E. Gripaldo, MD, Rochester, MN Faculty Discussant: S.I.S. Rounds, MD, Providence, RI 2:25 This Shall Not Pass D. Villafuerte, MD, San Antonio, TX Faculty Discussant: M. I. Schwarz, MD, Aurora, CO 2:35 This Zebra Has Spots J. Huston, MD, New Haven, CT Faculty Discussant: S.I.S. Rounds, MD, Providence, RI 2:45 When Hoof Beats Mean Unicorns C. Shappell, MD, Boston, MA Faculty Discussant: M.I. Schwarz, MD, Aurora, CO 2:55 Beauty and the Beast P. Cheng, MD, MS, Philadelphia, PA Faculty Discussant: P.C. Stillwell, MD, Aurora, CO 3:05 The Imitation Game W. Kareem, MD, Los Angeles, CA Faculty Discussant: S.I.S. Rounds, MD, Providence, RI 3:15 When Calcifications Belie Trouble T. Ku, MD, Kansas City, KS Faculty Discussant: M.I. Schwarz, MD, Aurora, CO 3:25 Radiologic Findings A.G. Wilcox, Los Angeles, CA 3:38 Pathologic Findings J.L. Myers, MD, Ann Arbor, MI 3:59 Master Clinicians S.I.S. Rounds, MD, Providence, RI M.I. Schwarz, MD, Aurora, CO P.C. Stillwell, MD, Aurora, CO BASIC • CLINICAL CRITICAL CARE TRACK CME Credits Available: 2 A84 JAMA AND THE NEW ENGLAND JOURNAL OF MEDICINE. DISCUSSION ON THE EDGE: REPORTS OF RECENTLY PUBLISHED CRITICAL CARE RESEARCH 2:15 p.m. - 4:15 p.m. KBHCCD Room D163/D165/D170/D172 (Level 1) This session will provide a forum for attendees to interact with the authors and editors about papers published in JAMA and the New England Journal of Medicine. Papers presented will be recent publications, selected by the editors, to be of significant importance to the field of critical care medicine. Attendees will have the opportunity to hear presentations directly from the author and address questions to both the authors and editors. The discussion is intended to provide a unique insight into these papers, the selection process, and how the research applies directly to the field of critical care medicine. Chairing: H. Bauchner, MD, Chicago, IL J. Drazen, MD, Boston, MA Speakers And Talks To Be Announced BASIC • CLINICAL • TRANSLATIONAL BASIC SCIENCE CORE CME Credits Available: 2 A85 LIVING AND DYING BY LIPIDS: RESOLVING INFLAMMATION AND TEMPTING CELL FATE Assemblies on Allergy, Immunology and Inflammation; Respiratory Cell and Molecular Biology; Respiratory Structure and Function 2:15 p.m. - 4:15 p.m. KBHCCD Ballroom D Two (Level 3) Target Audience Basic scientists, physiologists, allergists, pulmonologists, translational researchers, fellows and residents, and graduate trainees interested in lung pathophysiology Objectives At the conclusion of this session, the participant will be able to: • apply new understanding of the nature of lipid mediators as pro-inflammatory and pro-resolving factors for inflammation and tissue repair in the lung; • improve understanding of biological processes affected by lipid mediators, including ferroptosis, and how these determine cell function and fate in response to inhaled chemical stressors; • appreciate how new findings are being positioned to promote research direction and therapeutic strategies that target lipid mediator effects of cell fate, and inflammation and it's resolution. Inflammation and its resolution are active processes. Multiple complex pathways regulate the coordinated response of structural and immune cells after exposure to inhaled irritants, allergens and microbes. Initiation of acute inflammation is associated with oxidative stress leading to lipid peroxidation, changes in metabolic activity, and biosynthesis of pro-inflammatory and resolving-eicosanoids. Though acute inflammation is vital for host protection, return to health relies on endogenous, active resolution programs that restore host tissues to a non-inflamed state. Failure of active resolution permits persistence of inflammation that can lead to chronic disease. This session highlights emerging mechanisms that determine the fate of cells faced with environmental insult and oxidative stress; and how this is a determinant of inflammation and its resolution. Speakers will focus on pro-resolving lipid mediators, how their dysregulation results in chronic airway inflammation, and emerging opportunities to target lipid mediators to treat lung disorders. Chairing : P.J. Sime, MD, Rochester, NY C. Wheelock, PhD, Stockholm, Sweden R.S. Kelly, MPH, PhD, Boston, MA 2:15 Ferroptosis: Death by Lipid Peroxidation M.Conrad, PhD, Neuherberg, Germany 2:41 Endothelial Barrier-Enhancing and Anti-Inflammatory Effects of Oxidized Phospholipids K.G. Birukov, PhD, MD, Baltimore, MD 2:59 Targeting Oxidized Phosphatidylcholine to Prevent and Reverse Airway Inflammation, Hyperresponsiveness and Remodeling A.J. Halayko, BS(Hons), MSc, PhD, ATSF, Winnipeg, Canada ATS 2019 • Dallas, TX 100 SUNDAY • MAY 19