ATS 2020 Advance Program

of the history and a differential diagnosis. The expert radiologist and pathologist will interpret the imaging and pathology, respectively, which the expert clinician will then use to further the discussion and ultimately make a diagnosis. Chairing: K.M. Burkart, MD, MSc, ATSF, New York, NY A.G. Henderson, MD, Chapel Hill, NC 9:15 Clinical Expert A.H. Limper, MD, Rochester, MN M.P. Rivera, MD, ATSF, Chapel Hill, NC M.I. Schwarz, MD, Aurora, CO 10:27 Radiologist Expert J.R. Galvin, MD, College Park, MD 10:51 Pathologist Expert J.L. Myers, MD, Ann Arbor, MI CLINICAL • TRANSLATIONAL CRITICAL CARE TRACK B4 A POSITIVE APPROACH TO NEGATIVE TRIALS: MAKING SENSE OF CONFLICTING TRIALS IN CRITICAL CARE Assemblies on Critical Care; Clinical Problems; Respiratory Structure and Function 9:15 a.m. - 11:15 a.m. Target Audience This session will target critical care clinicians (attendings, fellows, nurses, respiratory therapists) as well as clinical researchers. Objectives At the conclusion of this session, the participant will be able to: • More appropriately select patients for Neuromuscular Blockade in ARDS based on recent clinical trials. • Improve understanding of the challenges of clinical research in critical care and more appropriately apply the results of clinical trials to daily practice. • Define consensus, evidenced-based strategies for the care of individual patients with critical illness. Evidenced based practice in critical care is complicated by contradictory evidence and overturned trials. Clinical researchers in critical care have begun to come to a consensus as to what the central challenges to reproducible clinical trials are in this area, but these factors may not be fully appreciated by the practicing clinicians who must incorporate trials into their practice. This session will offer an overview of the issues raised by recent landmark trials and seek to build a consensus approach to common practice dilemmas based on the results of those trials. Chairing: C.C. Hardin, MD, PhD, ATSF, Boston, MA B.T. Thompson, MD, Boston, MA 9:15 What Can We Learn from Negative Trials? H.C. Prescott, MD, MSc, Ann Arbor, MI 9:30 Don’t We Just Know? Physiologic Reasoning in the Absence of Clinical Data A. Malhotra, MD, ATSF, La Jolla, CA 9:45 Observational Trials Are Not the Answer B.T. Thompson, MD, Boston, MA 10:00 Panel Discussion 1 H.C. Prescott, MD, MSc, Ann Arbor, MI A. Malhotra, MD, ATSF, La Jolla, CA B.T. Thompson, MD, Boston, MA 10:15 Moving Beyond Mortality as an Endpoint E. Colantuoni, PhD, Baltimore, MD 10:27 Beyond P Value M.N. Gong, MS, MD, Bronx, NY 10:39 SoWhat Does It All Mean? APragmatic Approach to Practice in an Era of Negative Trials G.D. Rubenfeld, MD, MSc, Toronto, Canada 10:54 Panel Discussion 2 E. Colantuoni, PhD, Baltimore, MD M.N. Gong, MS, MD, Bronx, NY G.D. Rubenfeld, MD, MSc, Toronto, Canada ATS 2020 • Philadelphia, PA 68 MONDAY • MAY 18