ATS 2020 Advance Program

Chairing: M.E. Rebuli, PhD, Chapel Hill, NC L.S. Van Winkle, PhD, Davis, CA J.P. Reilly, MD, MSCE, Philadelphia, PA 9:15 Sex Differences in Respiratory Disease Programming: Insights from Cohort Studies and Need for an Exposomic Framework R.J. Wright, MD, MPH, New York, NY 9:35 Where There Is Smoke, There Are Sex Differences: Part 1 - Wildfire Smoke L.A. Miller, PhD, Davis, CA 9:55 Where There Is Smoke, There Are Sex Differences: Part 2 - Secondhand Tobacco Smoke A. Noel, PhD, MSc, BSc, Baton Rouge, LA 10:15 Can Sex and Environmental Exposures Make Your Flu Worse? M.E. Rebuli, PhD, Chapel Hill, NC 10:35 Sex Differences in Ozone Responses and the Influence of Diet and Microbiome H. Tashiro, MD, PhD, Saga, Japan 10:55 Sex Differences with Environmental Exposure: What Do We Know and Where Do We Go from Here? P. Silveyra, PhD, MSc, Chapel Hill, NC BASIC • TRANSLATIONAL SCIENTIFIC SYMPOSIUM A10 LINKING LUNG DEVELOPMENT AND CARCINOGENESIS: FROM PATHWAYS TO LUNGMAP AND THE PRECANCER ATLAS Assemblies on Thoracic Oncology; Respiratory Cell and Molecular Biology 9:15 a.m. - 11:15 a.m. Target Audience Translational and basic scientists interested in development, lung cancer, emerging technologies like single-cell sequencing, those interested in hearing about advances in the LungMAP Consortium and the Precancer Atlas Objectives At the conclusion of this session, the participant will be able to: • learn new findings about lung developmental pathways that have relevance in carcinogenesis. This will inform future research efforts and establish new collaborative approaches for the diagnosis, prevention, and treatment of lung cancer; • improve knowledge about the multi-center LungMAP Consortium and Precancer Atlas efforts, and to understand the strengths and limitations of single cell sequencing and other advanced profiling technologies; • learn new findings about new directions in lung cancer research. This will improve the learner’s knowledge on new advances in early diagnosis, biomarkers, prognosis, prevention, and treatment. This session will explore the links between lung development and lung carcinogenesis. There are many known and emerging links between the processes, and insights from the study of development continue to inform new directions in cancer research. Efforts like the LungMAP Consortium and the Precancer Atlas can accelerate this work. Chairing: E. Ostrin, MD, PhD, Houston, TX Z. Borok, MD, ATSF, Los Angeles, CA 9:15 Regulation of Lung Progenitor Cell Homeostasis and Tumorigenesis Z. Borok, MD, ATSF, Los Angeles, CA 9:39 Premalignancy of Lung Squamous Cell Carcinoma A. Spira, MD, Boston, MA 10:03 Premalignancy of Lung Adenocarcinoma H. Kadara, PhD, Houston, TX 10:27 Transcriptional Networks Regulating Lung Morphogenesis and Tumorigenesis J.A. Whitsett, MD, Cincinnati, OH 10:51 Fibrosis, Development, and Cancer H.A. Chapman, MD, San Francisco, CA ATS 2020 • Philadelphia, PA 42 SUNDAY • MAY 17