ATS 2020 Advance Program

(HGF/KGF/FGF10), Senolytics (mTOR/Rapamycin), and Morphogens (Wnt/Notch) Chairing: J.K. Burgess, PhD, Groningen, Netherlands W.P. Drake, MD, Nashville, TN E.R. Neptune, MD, Baltimore, MD 9:15 Towards Lung Regeneration: Tools and Mechanisms C. Dean, BSc(Hons), PhD, London, United Kingdom 9:45 Building and Rebuilding the Lung: Insights from the Human Embryo K. Lim, Cambridge, United Kingdom 10:15 Alveolarization in Lung Regeneration R.E. Morty, PhD, Giessen, Germany 10:45 Differentiation and Morphogenesis of the Pulmonary Mesenchyme C.M. Nelson, PhD, Princeton, NJ BASIC • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM A6 CONTROVERSIES IN SLEEP APNEA PATHOPHYSIOLOGY DEBATE Assembly on Sleep and Respiratory Neurobiology 9:15 a.m. - 11:15 a.m. Target Audience Clinicians and investigators who are interested in sleep disordered breathing and the future of the field. Objectives At the conclusion of this session, the participant will be able to: • learn new findings about non-genioglossus and genioglossus contributions to obstructive sleep apnea; • gain new findings about carotid chemoreflex contributions to central sleep apnea; • learn about the extent to which phenotyping has potential for guiding clinical interventions. Recent studies are challenging established theories about the mechanisms underlying obstructive and central sleep apnea and existing treatment paradigms. Leaders in the field will debate key controversies with the goals of highlight the exciting and underappreciated recent findings and identifying knowledge gaps for future treatment-focused physiological studies. Chairing: S.C. Veasey, MD, Philadelphia, PA J.H. Walsh, PhD, Nedlands, Australia J.E. Orr, MD, La Jolla, CA 9:15 Genioglossus Muscle Hypotonia as the Major Cause of Pharyngeal Obstruction During Sleep A. Jordan, PhD, Parkville, Australia 9:35 Non-Genioglossus Muscle Hypotonia as the Major Cause of Pharyngeal Obstruction During Sleep A. Oliven, MD, Haifa, Israel 9:55 Carotid Body Hyperreflexia as the Leading Cause of Central Sleep Apnea and Sympathoexcitation in Heart Failure J. Paton, PhD, Auckland, New Zealand 10:15 Pulmonary Congestion and Filling Pressures as the Leading Cause of Central Sleep Apnea and Sympathoexcitation in Heart Failure G. Lorenzi-Filho, MD, Sao Paolo, Brazil 10:35 Pathophysiological Endotypes Will Be Useful for Predicting Treatment Outcomes S.A. Sands, BSc, PhD, Cambridge, MA 10:55 Pathophysiological Endotypes Will Never Be Useful for Predicting Treatment Outcomes R.J. Schwab, MD, Philadelphia, PA BASIC • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM A7 SYSTEMS BIOLOGY PLATFORMS FOR DRUG REPURPOSING IN PULMONARY HYPERTENSION AND BEYOND Assemblies on Pulmonary Circulation; Respiratory Cell and Molecular Biology 9:15 a.m. - 11:15 a.m. Target Audience The primary professional audiences are pulmonary ATS 2020 • Philadelphia, PA SUNDAY • MAY 17 39