ATS 2020 Advance Program

11:15 The Metabolic Syndrome and PH-HFpEF M.T. Gladwin, MD, Pittsburgh, PA 11:55 LUNCH 12:55 Challenging Cases in PH-HFpEF: The Great Masquerader N. Al-Naamani, MD, MS, Philadelphia, PA 1:35 Panel Discussion 1:40 Pulmonary Venous Remodeling in PH-HFpEF J. Leopold, MD, Boston, MA 2:20 Break 2:35 Trials and Tribulations in PH-HFpEF T. Thenappan, MD, Minneapolis, MN 3:15 Clinical Trial Updates and Future Perspectives in PH-HFpEF M. Simon, MD, MS, Pittsburgh, PA 3:55 Closing Remarks J.A. Mazurek, MD, Philadelphia, PA BASIC • TRANSLATIONAL POSTGRADUATE COURSE PG12 HOW THE EXTRACELLULAR MATRIX INSTRUCTS LUNG REGENERATION: TRANSLATING TOOLS AND TECHNIQUES Pre-registration and additional fees required. Continental breakfast and box lunch included. Attendance is limited. Member: $350 In-Training Member: $200 Non-Member: $425 In-Training Non-Member: $300 Assemblies on Respiratory Cell and Molecular Biology; Allergy, Immunology and Inflammation; Clinical Problems; Pediatrics; Pulmonary Circulation; Respiratory Structure and Function 8:00 a.m. - 4:00 p.m. Target Audience Physicians, physician scientists, scientists, fellows and trainees with an interest in the area of lung regeneration, in particular how the extracellular matrix (ECM) drives proper function of resident and non-resident cell types Objectives At the conclusion of this session, the participant will be able to: • improve participants knowledge on ECM-driven effects in lung regeneration. To Identify opportunities for novel investigation into understudied aspects of lung matrix biology and cell-ECM interactions; • contrast the strengths and weaknesses of model systems and approaches recently developed to study lung ECM and cell-ECM interactions; • understand how advances in lung matrix biology are revealing new tools to initiate and maintain lung regeneration for future therapeutic options. The primary objective of this course is to provide comprehensive state of the art current approaches and findings that demonstrate ECM-driven cell function during lung injury, inflammation, and repair. The lectures of this PG course will feature the basics of the ECM, ECM scaffold bioengineering, ECM-cell interactions and, finally, how to modify the ECM as a therapeutic target in chronic lung diseases such as lung fibrosis, COPD or bronchiolitis obliterans. Chairing: O. Eickelberg, MD, ATSF, Aurora, CO D.J. Tschumperlin, PhD, Rochester, MN E.R. Neptune, MD, Baltimore, MD C.A. Staab-Weijnitz, PhD, Munich, Germany 8:00 Welcome and Introduction to the Course O. Eickelberg, MD, ATSF, Aurora, CO 8:15 Extracellular Matrix in Lung Development, Homeostasis, and Disease V.J. Thannickal, MD, Birmingham, AL 8:45 The Physical and Biochemical Properties of the Extracellular Matrix that Regulate Cell Fate E. Cukierman, PhD, Philadelphia, PA 9:15 Novel ECM Components Revealed by Deep Discovery Proteomics H. Schiller, PhD, Munich, Germany 9:45 General Discussion Topic A 10:00 Break 10:15 Lung Slices to Study Matrix Remodeling D.E. Wagner, PhD, Lund, Sweden ATS 2020 • Philadelphia, PA FRIDAY • MAY 15 13