ATS 2020 Advance Program

• improve understanding of the potential Breakthrough therapeutic approaches for Cystic Fibrosis and other chronic lung diseases. This session will summarize the current status of translational research progressing toward restoration of a functional mucociliary epithelium by cell, gene or gene targeting therapeutic approaches with a particular focus on Cystic Fibrosis. Chairing: A.L. Ryan (Firth), PhD, Los Angeles, CA F.J. Hawkins, ChB, MB, Boston, MA 1:00 Session Introduction: Lung Regeneration A.L. Ryan (Firth), PhD, Los Angeles, CA 1:06 A Patient's Perspective Speaker To Be Announced 1:11 Where and How to Target CF Airway Disease? S.H. Randell, PhD, Chapel Hill, NC 1:29 Ex Vivo Expansion of Basal Stem Cells S.D. Reynolds, PhD, Columbus, OH 1:47 Derivation of Lung Stem Cells From iPSC F.J. Hawkins, ChB, MB, Boston, MA 2:05 Cell Engraftment Into the Lung: Developing a Better Animal Model? K.R. Parekh, MBBS, Iowa City, IA 2:23 Targeting Lung Stem Cells for Precise Gene-Editing B.R. Davis, PhD, Houston, TX 2:41 In Utero Gene-Correction of Genetic Lung Disease E.E. Morrisey, PhD, Philadelphia, PA BASIC • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM D88 SLEEP DISORDERS: THE NEW RISK FACTOR FOR AGE-RELATED NEURODEGENERATIVE DISEASES? Assembly on Sleep and Respiratory Neurobiology 1:00 p.m. - 3:00 p.m. Target Audience Researchers, clinicians, early career researchers, training fellows, nurses, caretakers. Objectives At the conclusion of this session, the participant will be able to: • learn about the bi-directional relationship between sleep, sleep apnea and neurodegeneration; • learn about emerging evidence that sleep apnea may play a role in neurodegeneration including understanding the mechanistic pathways that underpin this relationship; • provide new strategies to manage the care of sleep disordered breathing in patients with neurodegenerative disease. Sleep disturbances and sleep apnea, are common in patients with cognitive impairment and neurodegenerative conditions; however there is a growing recognition that the relationship between sleep and neurodegeneration is bi-directional. This symposium will address essential gaps by discussing, mechanistic evidence that sleep disturbances and sleep apnea promote neurodegeneration; novel clinical evidence that sleep apnea is a risk factor for future cognitive decline and Alzheimer’s disease and understanding whether CPAP treatment may reduce risk; barriers to treating sleep apnea in dementia patients; and the role of sleep apnea in the development and treatment of Parkinson’s disease. Chairing: C.M. Hoyos, BSc(Hons), MPH, PhD, Glebe, Australia S. Chowdhuri, MD, MS, Detroit, MI R. Osorio, MD, New York, NY 1:00 Chair Introduction C.M. Hoyos, BSc(Hons), MPH, PhD, Glebe, Australia 1:02 Sleep in Dementia: A Carer’s Perspective Speaker To Be Announced 1:07 Sleep, Sleep Disorders and Neurodegeneration: A BI-Directional Relationship? S.L. Naismith, MAPS, CCN, Sydney, Australia ATS 2020 • Philadelphia, PA WEDNESDAY • MAY 20 145