ATS 2020 Advance Program

The session will highlight NICHD’s research programs and priorities that address major illnesses and comorbidities in pediatric infectious diseases, trauma and critical illness of relevance to ATS member clinicians who care for children. Chairing: B.G. Kapogiannis, MD, Bethesda, MD R.F. Tamburro, MD, MSc, Bethesda, MD 11:45 NICHD Research Priorities for Pediatric Pulmonary and Critical Illness Research R.F. Tamburro, MD, MSc, Bethesda, MD 12:15 NICHD Research Priorities in Pediatric Infectious Diseases B.G. Kapogiannis, MD, Bethesda, MD NATIONAL INSTITUTE ON DRUG ABUSE/NIH L23 THE OPIOID PUBLIC HEALTH CRISIS: SCIENCE = SOLUTIONS 11:45 a.m. - 12:45 p.m. Target Audience Researcher and clinician members of the American Thoracic Society, particularly those engaged in pulmonary, critical care, sleep medicine and other areas of research and clinical care with relevance to opioid misuse, addiction, and overdose. Objectives At the conclusion of this session, the participant will be able to: • improve understanding of how opioid analgesics effect respiratory systems and processes and contribute to opioid-related toxicity; • develop a better understanding of the role of fentanyl and other opioids in the development of wooden chest syndrome and its implications for treating opioid overdose patients who present with that syndrome; • develop a better understanding of how respiratory scientists can contribute to solutions to addressing the opioid public health crisis. The U.S. opioid crisis has resulted in almost 400,000 deaths between 1999-2017 from opioid overdoses. This session will address the evolution of the opioid crisis and the public health response mobilized to address it, as well as mechanisms of opioid-induced mortality with a focus on respiratory depression. The speakers will address the current understanding of respiratory control, how opioids affect respiration, and recent developments and gaps in research on mechanisms of central and peripheral respiratory control. Particular attention will be paid to mechanisms underlying opioid-induced “wooden chest” syndrome, a phenomenon coming under scrutiny as a potential contributor to opioid-induced mortality. Chairing: W.M. Compton, MD, MPE, Rockville, MD 11:45 Mobilizing a Public Health Response to the U.S. Opioid Crisis W.M. Compton, MD, MPE, Rockville, MD 12:00 Sites and Mechanisms of Action of Opioids on Breathing S.J. Lewis, PhD, Cleveland, OH 12:15 The Role of Opioids in “Wooden Chest” Syndrome P. Torralva, MD, Portland, OR 12:30 Moderated Questions and Answers A. Hampson, PhD, Rockville, MD U.S. FOOD AND DRUG ADMINISTRATION L24 PULMONARY UPDATE FROM THE U.S. FOOD AND DRUG ADMINISTRATION 11:45 a.m. - 12:45 p.m. Target Audience Clinicians in practice, academic researchers, pharmaceutical industry representatives, and international regulators. Objectives At the conclusion of this session, the participant will be able to: ATS 2020 • Philadelphia, PA 136 WEDNESDAY • MAY 20