ATS 2020 Advance Program

• define new strategies to identify patients at high risk for developing lung complications after hematopoeitic cell transplant; • integrate new options for the treatment of steroid-refractory lung disease after hematopoietic cell transplant. Lung complications after hematopoeitic cell transplant are common and often occur insidiously, leading to morbidity and mortality despite curing high-risk hematologic malignancies. This session will refresh attendees on the natural history of lung complications, update viewers on the safety of azithromycin after transplant, and highlight state-of-the-art advances in the detection of occult infections, novel thoracic imaging modalities, and cloud-based home spirometry platforms to detect and halt the progression of pulmonary diseases such as bronchiolitis obliterans. The session will conclude with cutting-edge treatments for steroid-refractory graft-versus-host disease of the lung, offering new options for those who care for patients with lung disease after hematopoeitic transplant. Chairing: A. Sheshadri, MD, BA, MSCR, Houston, TX G.-S. Cheng, MD, Seattle, WA 9:15 Lung Complications After HCT: Where Do We Stand in 2020? G.-S. Cheng, MD, Seattle, WA 9:35 Dysbiosis and Occult Viral Infections: Silent Instigators of Lung Disease D.N. O’Dwyer, BM BCH, BMedSci, PhD, Ann Arbor, MI 9:55 Imaging the Lung with 20/20 Vision: Early Indicators of Lung Impairment J.C. Woods, PhD, Cincinnati, OH 10:15 Bringing It Back Home: Early Detection with Home Spirometry Telemonitoring A. Sheshadri, MD, BA, MSCR, Houston, TX 10:35 ALLOZITHRO and Beyond: Reassessing the Safety of Azithromycin After Allogeneic HCT A. Bergeron, MD, PhD, Paris, France 10:55 Beyond Steroids: New Targets to Treat BOS and Other Late Lung Complications J.L. Hsu, MD, MPH, Redwood City, CA CLINICAL CLINICAL TOPICS IN PULMONARY MEDICINE C3 PEDIATRIC CLINICAL CHEST ROUNDS Assembly on Pediatrics 9:15 a.m. - 11:15 a.m. Target Audience Pediatric pulmonary clinicians, including physicians, NPs, nurses, and other health professionals interested in the diagnosis and management of challenging pediatric cases. Objectives At the conclusion of this session, the participant will be able to: • generate a broad differential diagnosis for challenging cases in pediatric pulmonary medicine; • apply current diagnostic testing to the management of challenging cases in pediatric pulmonary medicine; • discuss state of the art management of challenging pediatric pulmonary cases. Pediatric Clinical Chest Rounds focuses on the diagnosis and management of 4 challenging clinical cases selected from the case reports submitted to the Pediatric Assembly. Each case is presented by a trainee (usually a pediatric pulmonary fellow) and discussion is led by an expert in the field. Chairing: A.G. Filbrun, MD, MS, Ann Arbor, MI T.J. Moraes, MD, Toronto, Canada A.R. O’Hagan, MD, Louisville, KY 9:15 Case Presentation 1 A.G. Filbrun, MD, MS, Ann Arbor, MI 9:45 Case Presentation 2 A.R. O’Hagan, MD, Louisville, KY 10:15 Case Presentation 3 T.J. Moraes, MD, Toronto, Canada 10:45 Case Presentation 4 A.G. Filbrun, MD, MS, Ann Arbor, MI ATS 2020 • Philadelphia, PA TUESDAY • MAY 19 101