ATS 2019 Virtual Final Program

P859 8-CPT Attenuates Histone Sub-Unit 3 (H3) Induced Increase in Endothelial Permeability/ R. Baalachandran, S. Lee, T.T.T. Nguyen, Y. Ke, P. Karki, K. Tanaka, K.G. Birukov, A. Birukova, Baltimore, MD, p.A1970 P860 Protective Impact of Mild Pulmonary Thrombosis on Sepsis-Induced Lung Injury/ C. Evans, X. Zhang, Z. Dai, Y.-Y. Zhao, Chicago, IL, p.A1971 P861 Dynamic Modulation of Dipeptidyl Peptidase-4 in LPS-Induced Lung Injury in Mice/ T. Kawasaki, W. Chen, K. Tatsumi, S.M. Dudek, Chiba, Japan, p.A1972 P862 Phospholipase D2 Facilitates Recovery of Thrombin-Induced Endothelial Barrier Dysfunction by Regulating VE-Cadherin Phosphorylation/ P. Fu, M. Shaaya, Y. Komarova, R.D. Minshall, A. Karginov, V. Steven, A.B. Malik, V. Natarajan, Chicago, IL, p.A1973 P863 Acid Instillation in Alveoli Deteriorates the Endothelial Barrier by Depolymerizing F-Actin/ R.F. Hough, G.A. Gusarova, G. Jin, J. Bhattacharya, New York, NY, p.A1974 Facilitator : N. Al-Naamani, MD, MS, Philadelphia, PA P864 Gamma Secretase Activating Protein is Necessary for Endothelial Dysfunction and Production of Cytotoxic Beta Amyloid During Bacterial Infection/ M. Gwin, S.B. Voth, C.M. Francis, R. Balczon, T. Stevens, Mobile, AL, p.A1975 P865 Inhibition of Group V Phospholipase A 2 (gVPLA 2 ) Protects Lung Endothelium from Methicillin-Resistant Staph Aureus (MRSA) Induced Permeability/ Y.M. Htwe, L. Meliton, S.M. Dudek, Chicago, IL, p.A1976 P866 Circulating Heparan Sulfate Binds the Staphylococcus Aureus Toxin Alpha-Hemolysin (Hla), Attenuating Hla-Induced Pulmonary Endothelial Injury/ K. Oshima, S.A. McMurtry, K.I. Michael, J.A. Hippensteel, G. Su, F. Zhang, A.R. Horswill, J. Liu, R.J. Linhardt, E.P. Schmidt, Aurora, CO, p.A1977 P867 Endotoxin and Mechanical Stress Activate the Biosynthesis and Secretion of Placental Growth Factor/ E. Sylar, Y. Zhang, A. Vetticaden, A.D. Rice, T. Wang, Phoenix, AZ, p.A1978 P868 Lung Endothelium Produces Cytotoxic, Oligomer-Like Tau Fragments During Bacterial Infection/ A. deWeever, M. Gwin, S.B. Voth, C.M. Francis, R. Balczon, T. Stevens, Mobile, AL, p.A1979 Facilitator : A.M. Andruska, MD, Stanford, CA P869 Oxidant Stress Triggers Formation of Intra- and Extracellular Mitochondrial DNA Damage Associated Molecular Patterns (mtDNA Damps) in Human Endothelial Cells/ V. Pastukh, G. Bardwell, O. Gorodnya, M.N. Gillespie, Mobile, AL, p.A1980 P870 Pseudomonas Aeruginosa Exoenzyme Y Induces Caspase-3/7 Release Independent of Apoptosis in Pulmonary Microvascular Endothelial Cells/ P. Renema, T. Stevens, Mobile, AL, p.A1981 P871 TNFa-Mediated Differential Expression of MicroRNAs in Human Pulmonary Microvascular Endothelial Cells/ E. Ho, S. Gairhe, J. Sun, A.F. Suffredini, Bethesda, MD, p.A1982 P872 Right Ventricle-to-Left Ventricle Diameter Ratio Is a Poor Surrogate of RV Dysfunction in Patients with Left Ventricular Hypertrophy/ M. Nevulis, L.A. Myc, A. Barros, A.D. Mihalek, A. Sharma, N. Nuradin, A. Kadl, Charlottesville, VA, p.A1983 P873 Pulmonary Endothelium Generates Antimicrobial Prions as an Innate Defense Mechanism/ S.B. Voth, S. Piechocki, M.S. Gwin, C.M. Francis, T. Stevens, Mobile, AL, p.A1984 Facilitator : J.A. Hippensteel, MD, MS, Aurora, CO P874 Attenuation of Beta Amyloid Release During Pseudomonas Aeruginosa ExoY Intoxication Preserves Innate Antimicrobial Activity of Endothelial Amyloids/ S.B. Voth, M.S. Gwin, C.M. Francis, T. Stevens, Mobile, AL, p.A1985 P875 Clinical Strains of ExoY-Competent Pseudomonas Elicit Cytotoxic Endothelial Amyloid Prions/ S.B. Voth, M.S. Gwin, M. Crawford, L. Abou Saleh, C.M. Francis, J.-F. Pittet, B. Wagener, S. Moser, T. Stevens, Mobile, AL, p.A1986 P876 Measuring Regional Gas Uptake Using Hyperpolarized Xenon MRI in Injured Rabbit Lungs/ Y. Xin, K. Ruppert, M. Cereda, F. Amzajerdian, H. Hamedani, M. Pourfathi, S. Siddiqui, I. Duncan, L. Loza, T. Achekzai, F. Sertic, R. Baron, J. Ehrich, H. Profka, S. Kadlecek, R.R. Rizi, Philadelphia, PA, p.A1987 P877 Extrinsic Acidosis Suppresses Lung Endothelium Metabolism While Intrinsic Acidosis Does Not/ M. Onanyan, I. Garrison, R. White, M. Crook, T. Stevens, J.Y. Lee, Mobile, AL, p.A1988 P878 Hypoxia-Induced Pulmonary Inflammation and Cell Proliferation Are Complement- and Antibody-Driven/ M. Frid, B.A. McKeon, M. Li, T. Sullivan, H. Zhang, S. Kumar, J. Laskowski, J. Thurman, K.R. Stenmark, Aurora, CO, p.A1989 P879 Investigation into the Roles of Circulating Microvesicles Within the Pulmonary Vasculature Using Ex Vivo Isolated Perfused Lung/ Y.Y. Tan, K.P. O’Dea, A. Pac Soo, M. Takata, London, United Kingdom, p.A7317 BASIC • CLINICAL • TRANSLATIONAL THEMATIC POSTER SESSION A56 SYMPATHY FOR THE CLOT: UPDATE ON PULMONARY EMBOLISM AND CTEPH 9:15 a.m. - 4:15 p.m. KBHCCD Area F (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. Facilitator : V.F. Tapson, MD, West Hollywood, CA P881 Catheter-Directed Thrombolysis (CDT) for Intermediate and High Risk Pulmonary Embolism/ A. Singh, O. Charran, J. Filopei, A. Shujaat, D. Pan, R. Lookstein, J. Salonia, J.M. Shapiro, A. Isath, D. Steiger, New York, NY, p.A1990 ATS 2019 • Dallas, TX 74 SUNDAY • MAY 19