ATS 2019 Virtual Final Program

3:10 Translational Insights from the HIV Lung: Why it Matters in Non-HIV Lung Disease A.M. Morris, MD, MS, Pittsburgh, PA BASIC • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 2 D91 USING THE BASIC BIOLOGY OF IPF TO DESIGN NEW THERAPIES Assemblies on Respiratory Cell and Molecular Biology; Clinical Problems 1:30 p.m. - 3:30 p.m. KBHCCD Room C147/C148/C154 (Level 1) Target Audience Basic and translational scientists, clinical researchers, and clinicians interested in the mechanisms that underlie lung fibrosis and the bench to bedside development of emerging therapies for idiopathic pulmonary fibrosis Objectives At the conclusion of this session, the participant will be able to: • recognize the mechanisms by which epithelial cells, fibroblasts and macrophages contribute to the complex pathobiology of lung fibrosis; • understand how basic science discovery and mechanistic biology directly informs the development of feasible therapeutic strategies for the future treatment of IPF; • learn about emerging pre-clinical and clinical studies targeting specific biologic mechanisms in IPF. This session will highlight the bench to bedside development of emerging therapeutic strategies for idiopathic pulmonary fibrosis (IPF). Each speaker will discuss how discoveries of fundamental biologic mechanisms in the laboratory have identified novel, feasible and specific targets for current and future clinical trials. Chairing : J.C. Horowitz, MD, ATSF, Ann Arbor, MI T.M. Maher, MD, MSc, PhD, London, United Kingdom E.F. Redente, PhD, Denver, CO 1:30 Targeting TGF Beta Activation by Epithelial and Fibroblast Integrins D. Sheppard, MD, San Francisco, CA 1:54 License to Kill (Myofibroblasts): Targeting Apoptosis Pathways to Reverse Lung Fibrosis D. Lagares, PhD, MSc, Charlestown, MA 2:18 Targeting Occult Viral Infection and Immune Dysregulation in IPF J. Kropski, MD, Nashville, TN 2:42 Targeting Innate Immunity in IPF E. Herzog, MD, PhD, New Haven, CT 3:06 From Redox Biochemistry to a Phase II Clinical Trial in IPF V.J. Thannickal, MD, Birmingham, AL BASIC • TRANSLATIONAL MINI SYMPOSIUM D92 THE MICROBIOME AND LUNG DISEASE 1:30 p.m. - 3:30 p.m. KBHCCD Room D220/D227 (Level 2) Chairing: P.S. Lai, MPH, MD, Boston, MA R.P. Dickson, MD, Ann Arbor, MI Oral Presentations 1:30 Gut Microbiota from Amish but Not Hutterite Children Protect Germ-Free Mice from Experimental Asthma/ L.K. Honeker, A. Sharma, J. Gozdz, B. Theriault, K. Patil, J.A. Gimenes, Jr., A. Horner, V. Pivniouk, C. Igartua, M.M. Stein, M. Holbreich, E. von Mutius, C. Ober, J.A. Gilbert, D. Vercelli, Tucson, AZ, p.A7022 1:45 Sputum Metagenomic Profiling Identifies Altered Airway Microbiome in Severe Asthma Linked to Neutrophilic Airways/ P. Howarth, S. Bates, A. Versi, J.H. Riley, M. Loza, F. Baribaud, R. Djukanovic, K.F. Chung, P.J. Sterk, I.M. Adcock, Brentford, United Kingdom, p.A7023 2:00 Lower Airway Dysbiosis Is Necessary for Neutrophilic and Th17 Lower Airway Inflammation in a Pre-Clinical Model of Smoke Induced COPD/ B. Wu, R. Xiao, J.J. Tsay, I. Sulaiman, M.P. Goldklang, Y. Li, L. Perez, B. Franca, J. Carpenito, E. Olsen, K. Yie, J.M. D’Armiento, L.N. Segal, New York, NY, p.A7024 2:15 HIV COPD: Exploring the Role of Host Recognition and Response to the Lung Microbiome in Pulmonary Disease/ D.G. Dunlap, L. Yang, J.W. Ries, S. Qin, K. Li, A. Fitch, L. Huang, B.J. McVerry, B. Methe, A.M. Morris, Pittsburgh, PA, p.A7025 2:30 Alterations in Oral and Gut Microbiota in HIV-Infected Individuals Related to Pulmonary Function/ L. Yang, A. Fitch, K. Li, C. Koch, S.M. Nouraie, R. DeSensi, K. Ho, J. Martinson, B. Methe, A. Morris, Pittsburgh, PA, p.A7026 2:45 Microbiome Protects Against Pulmonary Fibrosis Through TLR5 Activation/ A. Solis, Y. Sakamachi, C. Johnson, M. Xiaoling, S. Hussain, C. Trempus, A.B. Rice, E.K. Silverman, Y. Zhang, F. Sciurba, A. Walts, I. Yang, D.A. Schwartz, S. Garantziotis, Durham, NC, p.A7027 3:00 Lung Tissue Bacterial Communities Vary by Patient but Not by Anatomical Lobe Sampled in End-Stage Idiopathic Pulmonary Fibrosis: The Microbiome in Lung Explants Study (Miles-IPF)/ G. Kitsios, R. Nettles, S. Winters, J. Sembrat, D. Kass, L. Yang, X. Wang, S. Qin, A. Fitch, K.O. Lindell, B. Methe, B.J. McVerry, M. Rojas, A.M. Morris, Pittsburgh, PA, p.A7028 3:15 Microbial Regulation of Lung Injury in Mice/ A.I. Sperling, N. Fei, V. Leone, G.M. Barron, K.A.M. Mills, J. Gilbert, C.L. Hrusch, Chicago, IL, p.A7029 ATS 2019 • Dallas, TX WEDNESDAY • MAY 22 377 WEDNESDAY AFTERNOON