ATS 2019 Virtual Final Program

CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 2 D87 BEYOND THE RIGHT HEART CATHETERIZATION: QUANTITATIVE METHODS FOR INTERROGATING THE PULMONARY CIRCULATION Assemblies on Pulmonary Circulation; Clinical Problems; Critical Care; Respiratory Structure and Function 1:30 p.m. - 3:30 p.m. KBHCCD Room D162/D164 (Level 1) Target Audience Clinicians, basic scientists, translational researchers, fellows, residents and graduate trainees seeking to learn novel insights into pulmonary hypertension and cutting edge approaches to quantitative assessment of the of pulmonary circulation Objectives At the conclusion of this session, the participant will be able to: • understand the role of innovative CT, MRI and PET techniques in the clinical classification, prognostication and therapeutic monitoring of patients with pulmonary hypertension; • describe the emerging role of imaging in the study of pathophysiology of pulmonary hypertension; • learn about novel noninvasive diagnostic techniques that inform emerging therapeutic strategies and research endeavors in pulmonary hypertension. Current challenges in pulmonary hypertension include diagnosis, prognosis, identification of treatment responsive subtypes and understanding physiologic response to therapy. Quantitative methods using imaging to characterize pulmonary vascular disease are increasingly becoming available to clinicians and researchers. In this symposium, we review a range of established and emerging methods of quantification of the structure and function of the pulmonary circulation, spanning from the parenchyma to the right ventricle. The audience will learn about the latest clinically available techniques as well as emerging methods that show promise. Chairing: K.R. Stenmark, MD, Aurora, CO P. Kohli, MD, Boston, MA F.N. Rahaghi, MD, PhD, Boston, MA 1:30 Forecasting Right Ventricular Dysfunction in Pulmonary Hypertension Using Cardiac MRI A. Vonk Noordegraaf, MD, PhD, Amsterdam, Netherlands 1:50 Imaging and RV/PA Coupling in Pulmonary Hypertension R.R. Vanderpool, PhD, Tucson, AZ 2:10 The Role of CT and MRI in Clinical Assessment of Pulmonary Hypertension D. Kiely, MD, Sheffield, United Kingdom 2:30 Emerging Utility of Pulmonary Artery Flow Measures in Pulmonary Hypertension A.J. Barker, PhD, Denver, CO 2:50 Imaging of the Parenchymal Pulmonary Vasculature F.N. Rahaghi, MD, PhD, Boston, MA 3:10 Regional Perfusion Patterns in Pulmonary Vascular Disease P. Kohli, MD, Boston, MA BASIC • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 2 D88 NEW-TROPHILS: AN OLD CELL WITH NEW TRICKS IN LUNG DISEASE Assemblies on Allergy, Immunology and Inflammation; Clinical Problems; Respiratory Cell and Molecular Biology; Respiratory Structure and Function 1:30 p.m. - 3:30 p.m. KBHCCD Room D221/D225/D226 (Level 2) Target Audience Pulmonologists, immunologists, critical care physicians, pulmonary fellows, infectious disease physicians Objectives At the conclusion of this session, the participant will be able to: • gain new findings related to neutrophil biology including new signaling pathways and cellular fates; • apply new neutrophil findings to pathology observed in lung disease; • identify new therapeutic approaches targeting PMN biology in the treatment consideration of patients with lung disease. As our immunologic understanding of chronic lung disease evolves, the neutrophil response has become an area of increased focus. Although many of these pathway have been delineated, it is clear that novel mechanisms of PMN-mediated inflammation and tissue injury are operative in these disorders. This session will highlight some of these pathways and potential therapeutic approaches to target these pathways in chronic lung disease. Chairing: A. Gaggar, MD, PhD, Birmingham, AL T.S. Blackwell, MD, Nashville, TN C.M. Doerschuk, MD, Chapel Hill, NC 1:30 Introduction C.M. Doerschuk, MD, Chapel Hill, NC 1:40 Prolyl Hydroxylase 2 Regulates a Critical Balance in Neutrophil Function S.R. Walmsley, MRCP(UK), BM BCH, MD, PhD, Edinburgh, United Kingdom 2:00 Neutrophil Reprogramming as a Key Trigger for Progressive Lung Damage R. Tirouvanziam, PhD, Atlanta, GA 2:20 Leukotriene A4 Hydrolase: A Janus Enzyme Critical in Neutrophil Influx R. Snelgrove, PhD, MA, BSc, London, United Kingdom 2:40 Neutrophil Exosomes Mediate Matrix Remodeling in Chronic Lung Disease D. Russell, MD, Birmingham, AL 3:00 Bacterial-Driven Neutrophil Recruitment Drives Airway Remodeling B.W. Richmond, MD, PhD, Nashville, TN 3:20 Putting It All Together... A. Gaggar, MD, PhD, Birmingham, AL ATS 2019 • Dallas, TX WEDNESDAY • MAY 22 375 WEDNESDAY AFTERNOON