ATS 2019 Virtual Final Program

11:45 High Efficiency Gene Editing of Primary Airway Epithelial Cells Using Viral and RNP CRISPR-Cas9 Methods M.A. Seibold, PhD, Denver, CO 12:00 Establishing a Primary Epithelial Cell Model Using Non-Lentiviral Delivery of CRISPR/Cas9 S. Siddiqui, PhD, Frisco, TX 12:15 Utilizing CRISPR/Cas9 to Insert Modifications to Model Rare Lung Diseases A.L. Ryan, PhD, Los Angeles, CA 12:30 High Throughput CRISPR-Based Analyses of Gene Function D.J. Erle, MD, San Francisco, CA 12:45 CRISPR Screening in Airway Smooth Muscle Cells Q. Lu, PhD, Boston, MA 1:00 In Vivo Delivery of Cas9 RNP and Donor DNA with Gold Nanoparticles N. Murthy, PhD, Berkeley, CA CLINICAL WORKSHOP CME Credits Available: 1.5 WS8 PREDICTIVE MODELING IN CRITICAL CARE: PRINCIPLES AND PRACTICE R Registration Fee: $75 (includes box lunch) Attendance is limited. Pre-registration is required. Assembly on Critical Care 11:45 a.m. - 1:15 p.m. KBHCCD Room D171/D173 (Level 1) Target Audience Clinicians and researchers practicing acute or critical care interested in utilizing predictive modeling tools for improved patient care Objectives At the conclusion of this session, the participant will be able to: • identify common pitfalls in applying machine learning and predictive modeling in critical care; • describe best practices for moving predictive models from computing environments into clinical practice; • evaluate learning opportunities for advancing individual and group skills in machine learning and data science. Health care is undergoing a profound change driven by emerging applications of advanced analytic techniques to clinical care and research. In particular, rapid expansions in the availability of large-scale data, machine learning and data science methods, and powerful computational platforms are making predictive modeling available at the point of care. This session will give participants an overview of key issues salient to predictive model development and deployment in critical care today. Chairing: V. Liu, MD, MS, Oakland, CA M.M. Churpek, MD, MPH, PhD, ATSF, Chicago, IL 11:45 Top 10 List: Things I Wish Someone Had Told Me About Clinical Predictive Modeling M.M. Churpek, MD, MPH, PhD, ATSF, Chicago, IL 12:05 In Silico to In Vivo: Moving Predictive Models into Real-World Settings V. Liu, MD, MS, Oakland, CA 12:25 Building a Data Science Team K.S. Mathews, MD, MPH, New York, NY 12:45 Panel Discussion V. Liu, MD, MS, Oakland, CA CLINICAL ADULT CLINICAL CORE CURRICULUM CME Credits Available: 1.5 MOC Points Available: 1.5 CC5 CRITICAL CARE CLINICAL CORE CURRICULUM I 11:45 a.m. - 1:15 p.m. KBHCCD Room D163/D165/D170/D172 (Level 1) Target Audience Practicing internists, subspecialists, registered nurses and advanced practice nurses in pulmonary, critical care, and sleep medicine who work in a clinical setting and are currently engaged in maintenance of certification Objectives At the conclusion of this session, the participant will be able to: • remain current with medical knowledge relevant to their practice in pulmonary, critical care, and sleep medicine; • evaluate their understanding of key skills and content areas in pulmonary, critical care and sleep medicine, as well as receive feedback on their comprehension of a result of a pre-test/post-test comparison; • support clinicians who are engaged in maintenance of certification activities by providing updates on subjects included in recertification requirements. The ATS Clinical Core Curriculum Symposia focus on a 3-year content cycle of key medical content in the areas of Pulmonary, Critical Care, and Sleep Medicine. The topics are also aligned with corresponding MOC Medical Knowledge modules. This symposium is intended to assist clinicians with staying current with the growth of information relevant to their medical practice, as well as provide an opportunity to evaluate individual knowledge and skills while earning MOC Medical Knowledge points. Chairing: M.M. Hayes, MD, Boston, MA B. Coruh, MD, Seattle, WA S. Pasnick, MD, Santa Fe, NM 11:45 Sodium Disorders B. Butcher, MD, Pittsburgh, PA 12:15 Continuous Renal Replacement Therapy J.H. William, MD, Boston, MA 12:45 Toxicology J.H. Badulak, MD, Seattle, WA ATS 2019 • Dallas, TX 368 WEDNESDAY • MAY 22