ATS 2019 Virtual Final Program

513 Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myofibroblasts in Systemic Sclerosis-Associated Interstitial Lung Disease/ E. Valenzi, M. Bulik, T. Tabib, C. Morse, J. Sembrat, H. Trejo Bittar, M. Rojas, R. Lafyatis, Pittsburgh, PA, p.A6083 514 Using Toponomics to Characterize Phenotypic Diversity in Alveolar Macrophages from Male Mice Treated with Exogenous SP-A1/ D.S. Phelps, V.M. Chinchilli, D. Shearer, X. Zhang, J. Weisz, J. Floros, Hershey, PA, p.A6084 515 Cell Lineage Defined by Single Cell Transcriptomics of the Sputum in Asthma/ X. Yan, Q. Liu, A. Mihaljinec, J.L. Gomez, L.E. Cohn, G.L. Chupp, New Haven, CT, p.A6085 516 The Impact of Regulatory Genetic Variants on the Developing Human Lung/ S. Sharma, C. Liu, A.T. Kho, R. Gaedigk, C.A. Vyhlidal, K.G. Tantisira, K. Kechris, S.T. Weiss, Aurora, CO, p.A6086 517 Identifying Gene Regulatory Networks of TREM-1 Response in Asthma/ D.C. Croteau-Chonka, K. Glass, I.M. Adcock, K.F. Chung, S.-E.K. Dahlén, B. De Meulder, R. Djukanovic, P.J. Sterk, B.A. Raby, Boston, MA, p.A6087 518 Integration of Sputum eQTL and GWAS Indicates IL-27/EBI3 Pathway Is Associated with Severe Asthma/ J.-H. Chu, X. Yan, A. Liang, B. Hu, J.L. Gomez, G.L. Chupp, New Haven, CT, p.A6088 519 Whole Transcriptome Cis-eQTL Analysis of the Nasal Airway Epithelium in Childhood Asthmatics Reveals Functional Asthma Risk Variants/ S. Sajuthi, B.A. Saef, C. Rios, M.T. Montgomery, J.L. Everman, A.C.Y. Mak, M. White, C. Eng, S. Oh, J. Rodriguez-Santana, E.G. Burchard, M.A. Seibold, Denver, CO, p.A6089 520 Smoking Mediates the Effect of Both Rare and Common Variants in Chromosome 15q25 Region on Pulmonary Function/ S.M. Lutz, M.-L.N. McDonald, C. Lange, M.H. Cho, E.K. Silverman, J.E. Hokanson, Boston, MA, p.A6090 521 Genome-Wide Association Study of Parametric Response Mapping in the COPDGene Study Dissects Genetic Contributions to Emphysema and Functional Small Airway Disease/ C. Benway, P. Sakornsakolpat, J. Ross, B.D. Hobbs, M.H. Cho, E.K. Silverman, Boston, MA, p.A6091 522 Integrative Omics to Discover Novel Subtypes in a Chronic Obstructive Pulmonary Disease Lung Tissue Cohort/ B.D. Hobbs, L. Chimakurthi, J.D. Morrow, X. Wang, Y.-Y. Liu, B.R. Celli, R. Bueno, G.J. Criner, D.L. DeMeo, C.P. Hersh, E.K. Silverman, M.H. Cho, Boston, MA, p.A6092 523 Single Cell Transcriptomics Reveals Gene Expression Changes and Cell Populations Associated with Bleomycin-Induced Pulmonary Fibrosis/ J. Koenitzer, E. Donnelly, H. Wu, S. Ramakrishnan, B.D. Humphreys, St. Louis, MO, p.A7462 524 Integration of Transcriptomic and Proteomic Data Identifies Biological Functions in Lung Cell Populations/ Y. Du, G. Clair, D. Al Alam, S. Danopoulos, D. Warburton, J. Kitzmiller, R. Misra, S. Bhattacharya, T.J. Mariani, G.S. Pryhuber, J.A. Whitsett, C. Ansong, Y. Xu, Cincinnati, OH, p.A7463 BASIC • CLINICAL • TRANSLATIONAL POSTER DISCUSSION SESSION D30 ASTHMA: WHAT’S NEW IN ASSESSMENT AND TREATMENT? 9:15 a.m. - 11:15 a.m. KBHCCD Ballroom D Three (Level 3) Poster Viewing 9:15-10:00 Discussion 10:00-11:15 Chairing: A.E. Dixon, MD, ATSF, Burlington, VT B. Marsh, MD, PhD, Portland, OR S.B. Fain, PhD, Madison, WI 601 Oscillometry Detects Different Airway Abnormalities That Manifest as MRI Ventilation Heterogeneity in Asthma and COPD/ R. Eddy, G.N. Maksym, R.J. Dandurand, G. Parraga, London, Canada, p.A6093 602 Asthma Symptoms Correlate with Impulse Oscillometry Measures in Adults but Not with Spirometry/ N. Kasinathan, A. Jobanputra, A.T. Scardella, P.M. Lehrer, New Brunswick, NJ, p.A6094 603 Impulse Oscillometry Improves Detection of Airway Hyperresponsiveness in Asthma/ A. Jobanputra, P.M. Lehrer, S.-E. Lu, R.A. Panettieri, F.S. Wamboldt, C.G. Irvin, A.T. Scardella, New Brunswick, NJ, p.A6095 604 Day-to-Day Variability in Home-Based Forced Oscillation Technique Parameters Correlates with Asthma Control and Exacerbation Burden in Pediatric Asthma Subjects/ A. Wong, K. Hardaker, P. Field, J. Huvanandana, G. King, H.K. Reddel, G. Jayasuriya, D.A. Fitzgerald, C. Pandit, H. Selvadurai, C. Thamrin, P.D. Robinson, Sydney, Australia, p.A6096 605 Comparison of Forced Oscillation Technique and Spirometry to Assess Inhaled Corticosteroid and Long-Acting Beta-Agonist Combination Therapy Effects on Respiratory Function in Asthmatic Patients: A Post-Hoc Analysis of Open-Label, Randomized, Cross-Over Trial/ H. Ohbayashi, T. Asano, S. Kudo, M. Ariga, Mizunami, Japan, p.A6097 606 Using FEV1/FVC to Predict Outcome of Methacholine Challenge Testing/ W. Wee, D. Wilson, T.J. Moraes, Toronto, Canada, p.A6098 607 Resistant Airflow Obstruction in Children with Asthma (ROCAS)/ D.A. Krich, W. Huang, C.S. Bakshi, L.A. Parton, A.J. Dozor, S. Krishnan, Valhalla, NY, p.A6099 608 Local fSAD Features Derived from CT Topological Parametric Response Maps Are Associated with Ventilation Defects on Hyperpolarized Gas MRI in Asthma/ D. Mummy, B.A. Hoff, P. Hotvedt, C. Hatt, K.J. Carey, A. Fortuna, W. Zha, M. Schiebler, R.L. Sorkness, L.C. Denlinger, N.N. Jarjour, C.J. Galban, S.B. Fain, Madison, WI, p.A6100 609 Ventilation Defects on Hyperpolarized Helium-3 MRI Are Predictive of 2-Year Severe Exacerbation Frequency in Asthma/ D. Mummy, K.J. Carey, M. Evans, W. Zha, M. Schiebler, R.L. Sorkness, L.C. Denlinger, N.N. Jarjour, S.B. Fain, Madison, WI, p.A6101 ATS 2019 • Dallas, TX WEDNESDAY • MAY 22 331 WEDNESDAY MORNING