ATS 2019 Virtual Final Program

413 Let’s Get Particulate About Matters on COPD - Acute Exacerbations of COPD in the Albuquerque, NM Area in Association to PM2.5/ M. Kakol, E. Sheehan, N. Phillips, R. Vazquez Guillamet, Albuquerque, NM, p.A6022 414 Particulate Matter Induces the Expression of Aconitate Decarboxylase 1, Which by Its Metabolite Itaconate Attenuates Inflammatory Response in Macrophages/ K. Sun, A.Y. Meliton, P.S. Woods, L.M. Kimmig, E.M. O’Leary, D. Wu, Y. Tian, R.B. Hamanaka, G.M. Mutlu, Chicago, IL, p.A6023 415 The Effect of Varying Doses and Duration of Particulate Matter (PM 2.5 ) Exposure on Myofibroblast Differentiation/ N. Craig, S.K. Huang, Ann Arbor, MI, p.A6024 416 Association Between Diesel Exhaust Inhalation and Black Carbon Loading in Airway Macrophages in Individuals with COPD/ C. Sack, C. White, M.H. Ryu, J.D. Kaufman, T. Kavanagh, C. Carlsten, Seattle, WA, p.A6025 417 The Protective Role of Airway Macrophages in Face of Air Pollution/ N.M. Liu, L. Miyashita, J.M. Grigg, London, United Kingdom, p.A6026 418 Recombinant Neuroglobin Reverses the Molecular Mitochondrial Effects of Carbon Monoxide Poisoning Through Carbon Monoxide Scavenging/ J.J. Rose, K.A. Bocian, Q. Xu, X. Chen, A.W. DeMartino, L. Wang, I. Azarov, X.N. Huang, Q. Tong, C.G. Corey, D. Guimaraes, C.F. McTiernan, C.P. O’Donnell, J. Tejero, S. Shiva, M.T. Gladwin, Pittsburgh, PA, p.A6027 419 Mouse Model of Pulmonary Fibrosis Induced by Intranasal Instillation of PM 2.5 / F. Li, M. Xu, Shanghai, China, p.A6028 420 The Effects of Dust on Human Bronchial Epithelium and Immune Cells/ H. Asif, C. Zhang, Z. Chauhan, A. Pourmand, N. Kumar, G. Conner, N. Fregien, M. Mirsaeidi, Miami, FL, p.A6029 BASIC • CLINICAL • TRANSLATIONAL RAPID: RAPID ABSTRACT POSTER DISCUSSION SESSION D27 MECHANISTIC INSIGHTS INTO BRONCHOPULMONARY DYSPLASIA 9:15 a.m. - 11:15 a.m. OMNI DALLAS DOWNTOWN Trinity Ballroom 1-3 (Level 3) Abstract Summaries 9:15-9:45 Viewing/Discussion 9:45-11:15 Chairing: T.E. Tipple, MD, Birmingham, AL B. Shivanna, MD, DM, PhD, Houston, TX S.H. Abman, MD, Aurora, CO 901 S1P/S1P1 and STAT3 Signaling Axis Promotes Hyperoxia- Induced Lysyl Oxidase in Lung Endothelium Leading to Bronchopulmonary Dysplasia/ A. Harijith, A.W. Ha, D.L. Ebenezer, P. Fu, T. Bai, S. Garzon, E. Berdyshev, G.S. Pryhuber, V. Natarajan, Chicago, IL, p.A6030 902 Novel Immunomodulatory Compounds to Prevent Bronchopulmonary Dysplasia/ V. Bhandari, P. Das, O. Kumova, S. Malaeb, D. Shah, B. Agarwal, A. Carey, A. Suchismita, Philadelphia, PA, p.A6031 903 Airway Microbial Dysbiosis Induced Neutrophilic Inflammation Leads to Bronchopulmonary Dysplasia-Like Phenotype in Mice/ K. Dolma, G. Rezonzew, T. Jilling, J.E. Blalock, A. Gaggar, N. Ambalavanan, C.V. Lal, Birmingham, AL, p.A6032 904 Toll-Like Receptor 4-Dependent Suppression of Platelet-Derived Growth Factor Receptor-Alpha Signaling: A Novel Mechanism for Inflammation-Induced Hypoalveolarization/ A.P. Popova, T.X. Cui, A. Brady, L. Rosenbloom, C. Fulton, A. Goldsmith, Ann Arbor, MI, p.A6033 905 Adiponectin Ameliorates Hyperoxia-Induced Lung Endothelial Dysfunction and Promotes Angiogenesis in Neonatal Mice/ D. Shah, P. Das, V.M. Prahaladan, G.S. Pryhuber, V. Bhandari, Philadelphia, PA, p.A6034 906 Role of Fatty Acid Oxidation in Hyperoxia-Induced EndoMT: Implication in Pathogenesis of Pulmonary Hypertension/ J. Gong, Z. Feng, X. Lu, A.L. Peterson, P.A. Dennery, H. Yao, Providence, RI, p.A6035 907 Conditional Smooth Muscle S-Nitrosoglutathione Reductase Deletion Attenuates Pulmonary Hypertensive Changes but Not Airway Hyperreactivity in a Hyperoxic Mouse Model of Bronchopulmonary Dysplasia/ T.M. Raffay, A. Jafri, R.B. Sopi, C.A. Hodges, R.J. Martin, B.M. Gaston, Cleveland, OH, p.A6036 908 Sex-Specific miR-30a Mediated Snai1 Inhibition Decreases Pathologic Fibrosis in BPD/ K. Lingappan, X. Dong, Y. Zhang, Houston, TX, p.A6037 909 Interferon Gamma Is Protective in Acute Hyperoxia-Induced Lung Injury/ L.C. Eldredge, R.S. Creasy, S.F. Ziegler, Seattle, WA, p.A6038 910 Endothelial Extracellular Signal-Regulated Kinase 2 (ERK2)-Deficient Mice Display Increased Susceptibility to Hyperoxia-Induced Experimental Bronchopulmonary Dysplasia and Pulmonary Hypertension/ B. Shivanna, A. Shrestha, C. Reynolds, R. Menon, Houston, TX, p.A6039 911 Transcriptional Characterization of Human Lung Cells Identifies Novel Markers for Mesenchymal Lineages/ S. Danopoulos, S. Bhattacharya, M. Thornton, B. Grubbs, T.J. Mariani, D. Al Alam, Los Angeles, CA, p.A6040 912 Developmental Transcriptome Signatures for Infant Airway Epithelium Reveals Discordance in Polymeric Immunoglobulin Receptor Expression Between Cell Cultures and Intact Lung/ T. Westmont, M.G. dela Pena-Ponce, D. Dugger, H. Ji, V. Kohli, L.A. Miller, Davis, CA, p.A6041 913 Hyaluronan Binding Peptide Treatment to Block Inflammasome Activation and Prevent Bronchopulmonary Dysplasia/ R.C. Savani, C. Longoria, N. Cheong, J. Liao, C. Tolg, L. Luyt, E.A. Turley, Dallas, TX, p.A6042 914 Impairment of Thioredoxin 1 Disrupts Perinatal Alveolar Development/ P. Vitiello, C. Aegerter, J. Hoffman, B. Mordhorst, A. Fairchild, B. Forred, T.E. Tipple, Sioux Falls, SD, p.A6043 ATS 2019 • Dallas, TX 328 WEDNESDAY • MAY 22