ATS 2019 Virtual Final Program

BASIC • TRANSLATIONAL RAPID: RAPID ABSTRACT POSTER DISCUSSION SESSION D21 HOST RESPONSE TO LUNG INFECTIONS 9:15 a.m. - 11:15 a.m. KBHCCD Ballroom A Four (Level 2) Abstract Summaries 9:15-9:45 Viewing/Discussion 9:45-11:15 Chairing: Y.J. Huang, MD, Ann Arbor, MI C. Dela Cruz, MD, PhD, ATSF, New Haven, CT R.S. Hagan, MD, PhD, Chapel Hill, NC 301 Insufficiency in Airway Interferon Activation Defines Clinically Severe Infant RSV Infection/ C. Chu, L. Wang, X. Qiu, M. McCall, A. Corbett, J. Holden-Wiltse, C. Slaunwhite, Q. Wang, C.S. Anderson, A. Grier, S.R. Gill, A.R. Falsey, D.J. Topham, M.T. Caserta, E.E. Walsh, T.J. Mariani, Rochester, NY, p.A5898 302 Intranasal Administration of Catalase Ameliorates Respiratory Syncytial Virus-Induced Airway Disease Via Modulation of Innate Immune Responses/ M. Ansar, T. Ivanciuc, A. Casola, R.P. Garofalo, Galveston, TX, p.A5899 303 Human Lung Fibroblasts Exposed to Respiratory Syncytial Virus or Human Rhinovirus 16 Generate a Hyaluronan-Enriched Extracellular Matrix That Binds and Activates Eosinophils and Mast Cells/ S.R. Reeves, I. Kang, K.A. Barrow, L.M. Rich, M.P. White, N.J. Shubin, A.M. Piliponsky, T.N. Wight, J.S. Debley, Seattle, WA, p.A5900 304 Rhinovirus C15 Infection Induces Eosinophilic Inflammation and Airways Hyperresponsiveness in Naïve and Allergen-Challenged Mice/ C. Rajput, T. Ishikawa, M. Han, J. Lei, J.K. Bentley, M.B. Hershenson, Ann Arbor, MI, p.A5901 305 Correlation of Longitudinal Breath Monitoring by Electronic Nose to Biomarker Profiles Before and After Rhinovirus Challenge in Humans/ A. Sinha, B. Xu, R. de Vries, J.W.F. Dagelet, A.H. Maitland-van der Zee, R. Lutter, U. Frey, P.J. Sterk, Amsterdam, Netherlands, p.A5902 306 Lung Memory B Cell Populations After Influenza Infection in Mice/ M. Breen, F. Feng, K. Barker, A. Hua, Y.M. Wang, T.B. Kepler, J.P. Mizgerd, R. Fearns, Boston, MA, p.A5903 307 Interferon Receptor 2 (IFNAR2) Regulates the Damage Response During Aspergillus and Influenza Pulmonary Infection/ K. Shepardson, L.L. Johns, Z. Malkoc, A. Rynda-Apple, Bozeman, MT, p.A5904 308 The Aryl-Hydrocarbon Receptor Drives Production of IL-17 and Exacerbates Pneumonitis and Pulmonary Fibrosis in Response to Respiratory Infections Following Bone Marrow Transplantation/ S.J. Gurczynski, B.B. Moore, Ann Arbor, MI, p.A5905 309 Pneumococcal Exposures Elicit Resident Memory B Cells in the Lung/ K. Barker, N.M.S. Smith, I.M.C. Martin, M.R. Jones, L.J. Quinton, J.P. Mizgerd, Boston, MA, p.A5906 310 Treatment with Small Peptides Derived from the Carbohydrate Region of Surfactant Protein-A2 Differentially Regulate Inflammatory Responses During Mycoplasma Pneumoniae Infection/ U.S. Younis, M. Kraft, J.G. Ledford, Tucson, AZ, p.A5907 311 Genetic and Infectious Regulators of Baseline and Acute Immunity in Human Populations/ A. Souquette, C. Oshansky, E.K. Allen, L. Tang, B. Ogunjimi, S. Schultz-Cherry, R. Webby, A. Gordon, P.G. Thomas, Memphis, TN, p.A5908 312 Heightened Erythrocyte Disposal Weakens Macrophage Effector Function During Klebsiella Pneumoniae Infection/ T.F. Olonisakin, Z. Xiong, S.N. Sarkar, J. Lee, Pittsburgh, PA, p.A5909 313 IL-22BP Regulates IL-22 Activity, Host Defense and Oxidative Phosphorylation Genes During Pneumococcal Pneumonia/ G. Trevejo-Nunez, W. Elsegeiny, Z. Kaplan, P. Castillo, K. Chen, J.K. Kolls, S.L. Gaffen, Pittsburgh, PA, p.A5910 314 Acid Aspiration Leads to Depletion of Resident Alveolar Macrophages and Impairs Their Bactericidal Activity/ U. Matt, C. Malainou, J. Wilhelm, W. Seeger, S. Herold, Giessen, Germany, p.A5911 315 Functions of TANK-Binding Kinase 1 (TBK1) in Neutrophils During S. Pneumoniae Pneumonia/ R.S. Hagan, J.C. Gomez, J.L. Torres-Castillo, J.R. Martin, C.M. Doerschuk, Chapel Hill, NC, p.A5912 316 Pirfenidone Treatment Improves Mitochondrial Dysfunction in Aged Macrophages and Lung During Primary Streptococcus Pneumoniae Infection/ R. Harris, M. Plataki, S.J. Cho, K. Schiffer, H. Stout-Delgado, New York, NY, p.A5913 317 RIPK3 Activates MLKL-Driven Necroptosis and NLRP3 Inflammasome in Macrophages to Protect Against Streptococcus Pneumoniae/ H. Huang, R. Harris, H.S. Yun, S.J. Cho, A.M.K. Choi, J.-F. Xu, H.W. Stout-Delgado, New York, NY, p.A5914 318 The Macrophage Response to Klebsiella Pneumoniae Involves CD36-Mediated Syk Activation and Type I IFN-Dependent Cytokine Production/ R. van der Geest, H. Li, J.S. Lee, Pittsburgh, PA, p.A5915 319 Acquisition of a Novel Acyltransferase Promotes Persistence of Carbapenem-Resistant K. Pneumoniae (CRKP) Pneumonia/ D. Ahn, V. Castano, T. McConnville, K. Liimatta, A.-C. Uhlemann, A.S. Prince, New York, NY, p.A5916 320 Bacterial Metabolic Adaptation Causes Chronic Lung Infection in Cystic Fibrosis/ S.A. Riquelme, C. Lozano, A. Moustafa, A. Narechania, E. DiMango, Y. Saenz, P.J. Planet, A.S. Prince, New York, NY, p.A5917 321 Transient Receptor Potential Vanilloid 4 (TRPV4) Regulates the Host Defense Response to Bacterial Pneumonia Through a MAPK Molecular Switch/ R.G. Scheraga, S. Abraham, L. Grove, B.D. Southern, J. Crish, T. Hamilton, C. McDonald, M.A. Olman, Cleveland, OH, p.A5918 322 Rhinovirus Infected Airway Epithelial Cells from Children with Asthma Enhance the Type-2 Immune Environment in Mast Cells/ M.C. Altman, Y. Lai, J.A. Hamerman, A. Lacy-Hulbert, S.R. Reeves, A.M. Piliponsky, K.A. Barrow, W.A. Altemeier, S.F. Ziegler, J.S. Debley, T.S. Hallstrand, Seattle, WA, p.A7455 ATS 2019 • Dallas, TX 322 WEDNESDAY • MAY 22