ATS 2019 Virtual Final Program

9:55 Statins: Good for the Heart and Good for TB? P.C. Karakousis, MD, Baltimore, MD 10:15 Metabolic Targeting with Metormin as Host-Directed Therapy for Tuberculosis B. Podell, DVM. PhD, DACVP, Fort Collins, CO 10:35 Can HDT Prevent TB Infection, Reinfection, and Progression? E.A. Nardell, MD, Boston, MA BEHAVIORAL • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 2 D10 BUILDING BLOCKS OF IMPLEMENTATION: HOW TO IMPLEMENT ICU EVIDENCE-BASED CARE Assemblies on Behavioral Science and Health Services Research; Critical Care; Nursing; Quality Improvement and Implementation Committee 9:15 a.m. - 11:15 a.m. OMNI DALLAS DOWNTOWN Trinity Ballroom 4/8 (Level 3) Target Audience Nurses, physicians, allied health professionals, junior physicians Objectives At the conclusion of this session, the participant will be able to: • define steps in implementation of evidence based care; • identify how to determine barriers to a particular care practice; • increase awareness of importance of evaluation in implementation of evidence based care in the ICU. Translating evidence based care into clinical practice is hard. Extending the scientific symposium in ATS 2017 that introduced participants to implementation science, this session will provide practical steps that ICU clinicians can use to implement evidence based practices (EBP) in community and academic settings, with or without research expertise. ICU clinicians and researchers alike are clamoring for guidance on the how to of implementation and this session will provide foundational knowledge using case based examples of the 5 key steps of implementation. Chairing: D.K. Costa, PhD, RN, Ann Arbor, MI C.H. Weiss, MD, MS, Skokie, IL C.T.L. Hough, MD, MSc, Seattle, WA 9:15 Overview of 5 Steps of Implementation L.C. Feemster, MSc, MD, Seattle, WA 9:30 Evidence-Based Ventilatory Management: What to Implement? C.H. Weiss, MD, MS, Skokie, IL 9:45 In Their Own Words: Assessing Qualitative Barriers to Early Mobilization M. Eakin, PhD, Baltimore, MD 10:00 At Scale: Assessing Barriers to Minimal Sedation S. Mehta, MD, Toronto, Canada 10:15 As Routine as Family Meetings? Tailoring the Implementation J.B. Seaman, PhD, RN, Pittsburgh, PA 10:30 Just Do It! Implementing an ICU Safety Checklist J. Stevens, MD, MS, Boston, MA 10:45 Evaluation Is the Key to Success C.T.L. Hough, MD, MSc, Seattle, WA 11:00 Question and Answer C.H. Weiss, MD, MS, Skokie, IL BASIC • TRANSLATIONAL MINI SYMPOSIUM D11 ALL CELLS ON DECK: IMMUNE CELLS AND THE PATHOGENESIS OF LUNG INJURY 9:15 a.m. - 11:15 a.m. KBHCCD Room D220/D227 (Level 2) Chairing: R.G. Scheraga, MD, Cleveland, OH R.M. Tighe, MD, Durham, NC R. Zemans, MD, Ann Arbor, MI Oral Presentations 9:15 Regulatory T Cell Subsets Differentially Regulate the Immune Response to Influenza/ J. Griffith, L. Faustino, A. Luster, Boston, MA, p.A5829 9:30 Origin, Location, and Fate of Murine Interstitial Macrophages Following Lung Injury/ A. McCubbrey, S.A. Hott, S.M. Thomas, P.M. Henson, W.J. Janssen, Denver, CO, p.A5830 9:45 Alveolar Macrophage Expression of Cholesterol 25 Hydroxylase Is Associated with Increased Inflammation and Lung Injury in ARDS/ E.D. Morrell, J. Madenspacher, R.D. Stapleton, C. Mikacenic, M.B. Fessler, M.M. Wurfel, Seattle, WA, p.A5831 10:00 Siglec-F Determines Lung Immunity Through Regulation of Macrophage Gap Junctions/ L. Li, G.A. Gusarova, M.N. Islam, J. Bhattacharya, New York, NY, p.A5832 10:15 Obesity Alters the Pulmonary Innate Immune System Response in Murine Acute Respiratory Distress Syndrome/ M. Kokoszynska, N. Ubags, L.D. Hoyt, B.T. Suratt, Burlington, VT, p.A5833 10:30 IL-5 Signaling Protects from Lung Edema and Mortality in Murine Models of Acute Respiratory Distress Syndrome/ C.L. Hrusch, K. Mills, R. Voogt, P. Krishack, D. Decker, K. Blaine, A.I. Sperling, Chicago, IL, p.A5834 10:45 Platelets Limit Apoptotic Lung Epithelial Cell Death and Protect Mice Against Infection-Induced Lung Injury/ W. Bain, T. Olonisakin, M. Yu, Y. Qu, M. Hulver, Z. Xiong, H. Li, J.M. Pilewski, R.K. Mallampalli, S.M. Nouraie, A. Ray, P. Ray, Z. Cheng, R. Shanks, C. St. Croix, R. Silverstein, J. Lee, Pittsburgh, PA, p.A5835 11:00 Interferon-Gamma Affects the Pace of Resolution Following Acute Lung Injury/ J.R. Mock, M.K. Tune, C.F. Dial, D. Norton, C.M. Doerschuk, Chapel Hill, NC, p.A5836 ATS 2019 • Dallas, TX WEDNESDAY • MAY 22 317 WEDNESDAY MORNING