ATS 2019 Virtual Final Program

Obstructive Sleep apnea (OSA) is associated with higher cancer incidence, tumour aggressiveness and cancer mortality. Basic, translational and clinical studies demonstrate the impact of intermittent hypoxia (IH) and sleep fragmentation (SF) on tumor incidence and progression. Sleep disturbance seem to confer a higher risk to develop some type of cancers. Recently several studies have focused on investigating whether sleep disordered breathing affect overall cancer outcomes. This session will focus on the epidemiology, IH and SF mediated pathophysiological pathways that contribute to cancer biology, immunological mechanisms, tumor microenvironment, and the role of circulating exosomes in both cancer and OSA. Chairing: L. Kheirandish-Gozal, MD, MSc, ATSF, Columbia, MO M. Sanchez De La Torre, PhD, Lleida, Spain B. Prasad, MD, Chicago, IL 9:15 Immune Deregulation in OSA as a Booster of Cancer Incidence, Tumor Aggressiveness and Cancer Mortality I. Almendros, PhD, Barcelona, Spain 9:45 A Message in a Bottle: Exosomes and Tumor Malignancy in OSA D. Gozal, MD, MBA, ATSF, Columbia, MO 10:15 OSA and Types of Cancer: An Epidemiological Overview J.-L. Pepin, MD, PhD, Grenoble, France 10:45 Future Perspectives in Lung Cancer: Do We Need to Take Sleep into Account? R.A. Winn, PhD, Chicago, IL CLINICAL SCIENTIFIC SYMPOSIUM CME Credits Available: 2 D6 SITES FOR PULMONARY REHABILITATION: WHERE CAN AND SHOULD IT BE PERFORMED? Assemblies on Pulmonary Rehabilitation; Clinical Problems; Nursing; Pulmonary Rehabilitation 9:15 a.m. - 11:15 a.m. KBHCCD Room D162/D164 (Level 1) Target Audience Physicians, nurses, respiratory therapists, physical therapists, occupational therapists, psychologists, and others who provide pulmonary rehab services Objectives At the conclusion of this session, the participant will be able to: • list three types of program settings for the provision of pulmonary rehabilitation services; • list three advantages for a home based pulmonary rehabilitation program; • develop a pulmonary rehabilitation program within a long term acute care or skilled nursing facility. This session will discuss the various types of settings used for pulmonary rehabilitation including outpatient, home, long term acute care, and research settings. Comparisons of each will be made with implications for the provision of such services for an individualized patient Chairing: B.W. Carlin, MD, Sewickley, PA 9:15 Pulmonary Rehabilitation: The “Traditional Setting” B.W. Carlin, MD, Sewickley, PA 9:40 Telehealth and Rehabilitation: Where Do We Stand? A.E. Holland, PhD, Melbourne, Australia 10:05 Pulmonary Rehabilitation in the Home and Research Settings J.M. Bon, MD, MS, Pittsburgh, PA 10:30 Pulmonary Rehabilitation in the Long Term Acute Care Setting S. Hammerman, MD, Mechanicsburg, PA 10:55 Question and Answer Period BASIC • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 2 D7 EXOSOMES: WEAPONS OF MASS DESTRUCTION Assemblies on Respiratory Cell and Molecular Biology; Allergy, Immunology and Inflammation; Pediatrics; Pulmonary Circulation; Sleep and Respiratory Neurobiology 9:15 a.m. - 11:15 a.m. KBHCCD Room D221/D225/D226 (Level 2) Target Audience Basic, clinical and translational researchers involved in understanding exosome mediated immune regulation and lung vascular injury Objectives At the conclusion of this session, the participant will be able to: • describe the role of exsosomes/EVs in immune regulation; • understand the role of exosomes in mediating vascular injury and cellular crosstalk; • discuss the application of exosomes/EVs in understanding the pathogenesis of lung diseases including ARDS/ALI, vascular lung diseases, lung cancer, IPF and COPD. Immune regulation and vascular injury play critical roles in multiple lung diseases Exosomes/exosomal vesicles (EVs) are small membrane-coated structures that are released from cells upon activation or during apoptosis. In pathological states, such as atherosclerosis, sepsis, acute lung injury, acute coronary syndrome, diabetes or immune disorders, elevated circulating levels of EVs have been detected. However, the role and sources of these extracellular vesicles in host pathogen response, immune regulation and cell fate in the lung remains incompletely understood. This symposium will serve to provide a comprehensive review of our current knowledge of exosomes/EVs in immune regulation and lung vascular injury, with applications to a broad spectrum of lung diseases including asthma, COPD, pulmonary vascular diseases, obstructive sleep apnea, pulmonary fibrosis, lung cancer, and infection. Chairing: A. Sarkar, PhD, Columbus, OH L.A. Ortiz, MD, Pittsburgh, PA J.R. Klinger, MD, Providence, RI 9:15 Introduction to Extracellular Vesicles in Vascular Injury and Pulmonary Medicine L.A. Ortiz, MD, Pittsburgh, PA ATS 2019 • Dallas, TX WEDNESDAY • MAY 22 315 WEDNESDAY MORNING