ATS 2019 Virtual Final Program

BASIC • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 2 C86 LUNGMAP-ING CELL LINEAGES IN HUMAN DEVELOPMENT AND DISEASE Assemblies on Pediatrics; Respiratory Cell and Molecular Biology 2:15 p.m. - 4:15 p.m. OMNI DALLAS DOWNTOWN Trinity Ballroom 4/8 (Level 3) Target Audience Researchers, investigators in basic and clinical science, clinical and research fellows in pulmonology training, clinical and research scientists interested in human lung development and disease; junior professionals Objectives At the conclusion of this session, the participant will be able to: • understand the latest advances in our knowledge of human lung development; • identify innovative approaches for defining the molecular and functional attributes of human lung cells; • better understand the different cell types in the developing human lung. Most of our knowledge of lung development and cell lineage hierarchy is derived from animal models. Therefore, there exists an important gap of knowledge in our understanding of cell lineages and cell fates in human lung development, and how they may relate to lung disease. In order to address these knowledge gaps, the LungMap Consortium has begun to create a molecular and cellular atlas of the developing mouse and human lung. This session will provide an overview of several novel aspects of human lung development, uncovered by the application of innovative technologies by experts in the field, with a focus on cell lineage and cell fate. Chairing: D. Al Alam, PhD, MS, Los Angeles, CA T.J. Mariani, PhD, Rochester, NY A.T. Perl, PhD, Cincinnati, OH N. Ambalavanan, MD, Birmingham, AL 2:15 Human Lung Development and Congenital Lung Abnormalities G. Deutsch, MD, Seattle, WA 2:40 Epigenetic Regulation of Cell Lineages in Human Lung Development J.S. Hagood, MD, Chapel Hill, NC 3:05 Transcriptomic Lineage Mapping of the Developing Human Lung M. Guo, PhD, Cincinnati, OH 3:25 Multi-Omic Characterization of the Lung During Development C. Ansong, PhD, Richland, WA 3:50 Immune Cell Development in Children, Measured in Lung, Spleen and Blood G.S. Pryhuber, MD, Rochester, NY BEHAVIORAL • CLINICAL • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 2 C87 PHYSIOLOGICALLY-GUIDED MECHANICAL VENTILATION Assemblies on Respiratory Structure and Function; Critical Care 2:15 p.m. - 4:15 p.m. KBHCCD Ballroom D One (Level 3) Target Audience Providers involved in administering mechanical ventilation to critically ill patients. Basic and translational scientists studying mechanisms of ventilator-induced lung injury. Objectives At the conclusion of this session, the participant will be able to: • articulate the principle mechanisms of ventilator -induced lung injury; • describe the key shortcomings of the current approaches to ventilator management of ARDS patients; • list 2-4 novel approaches that are currently being investigated for the assessment of individual patient status during mechanical ventilation. This symposium will cover various approaches in which mechanical ventilation can be delivered in a manner that is optimal for a given patient based on an understanding of that patient’s unique physiological status and the manner in which the stresses and strains of mechanical ventilation can worsen existing lung injury. Chairing: D.W. Kaczka, MD, PhD, Iowa City, IA C.E. Perlman, PhD, Hoboken, NJ J.H.T. Bates, PhD, DSc, ATSF, Burlington, VT 2:15 Linking Mechanical Ventilation to the Development of Lung Injury J.H.T. Bates, PhD, DSc, ATSF, Burlington, VT 2:35 Maintaining Low Surface Tension to Minimize Ventilation Injury C.E. Perlman, PhD, Hoboken, NJ 2:55 What You See and What You Get: PET/CT Insights on Mechanical Ventilation M.F. Vidal Melo, MD, PhD, Boston, MA 3:15 Identifying Targets to Guide Mechanical Ventilation: The Injury Cost Function B.J. Smith, PhD, Aurora, CO 3:35 Evolution of Lung Injury Using Quantitative CT Imaging M. Cereda, MD, Philadelphia, PA 3:55 Optimizing Ventilation in the Heterogeneous Lung: An Engineering Perspective D.W. Kaczka, MD, PhD, Iowa City, IA ATS 2019 • Dallas, TX TUESDAY • MAY 21 293 TUESDAY AFTERNOON