ATS 2019 Virtual Final Program

P1114 Pulmonary Emphysema in Rats with Severe Pulmonary Hypertension Induced by SU5416 and Hypoxia/ B. Kojonazarov, S. Hadzic, H.A. Ghofrani, F. Grimminger, N. Weissmann, W. Seeger, R.T. Schermuly, Giessen, Germany, p.A5043 P1115 Schistosoma Japonicum Can Induce Pulmonary Hypertension in Mice/ B. Kassa, R. Kumar, C. Mickael, L. Sanders, D. Koyanagi, R.M. Tuder, B.B. Graham, Aurora, CO, p.A5044 P1116 Synchrotron Phase Contrast Micro-CT as a Novel Tool for Understanding Pulmonary Vascular Pathobiology and the 3D Micro-Anatomy of Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins/ K. Tran-Lundmark, C. Westöö, C. Norvik, N. Peruzzi, G. Lovric, O. van der Have, R. Mokso, I. Jeremiasen, H. Brunnström, C. Galambos, M. Bech, Lund, Sweden, p.A5045 Facilitator : M. Gu, MD, PhD, Palo Alto, CA P1117 Exercising Skeletal Muscle Blood Flow Is Diminished in a Rat Model of Pulmonary Arterial Hypertension/ M. Brown, G.M. Long, A.L. Frump, A. Troutman, A. Fisher, K. Avin, A. Coggan, T. Lahm, Seattle, WA, p.A5046 P1118 Pressure Myography Implicates Altered Purinergic Signaling in the Pathobiology of the Sugen Rat Model of Pulmonary Hypertension/ P. Robichaud, C. Johnson, D. Petrovic-Djergovic, D.J. Pinsky, S.H. Visovatti, Ann Arbor, MI, p.A5047 P1119 Identification of Insulin-Like Growth Factor Binding Protein-2 (IGFBP2) as a Novel Biomarker for Pulmonary Arterial Hypertension Severity and Survival/ J. Yang, M. Griffiths, M. Nies, R. Damico, D. Vaidya, M. Pauciulo, W. Nichols, D. Ivy, E. Austin, A. Everett, Baltimore, MD, p.A5048 P1120 Pain Assessment After Intraplantar Injection of a Remodulin Equivalent Formulation and Subcutaneous Injection of Treprostinil in Rats/ M.R. Corboz, A.J. Plaunt, Z. Li, V. Malinin, H. Yin, C.E. Laurent, D. Salvail, W.R. Perkins, R.W. Chapman, Bridgewater, NJ, p.A5049 Facilitator : A.L. Frump, MS, PhD, Indianapolis, IN P1121 Transient Receptor Potential Canonical Channel 4 Modulates the Spread of Basal Pulmonary Artery Endothelial Calcium Signals in Pulmonary Arterial Hypertension/ J. Knighten, M. Taylor, T. Stevens, C.M. Francis, Mobile, AL, p.A5050 P1122 MMP-8 Deficiency Promotes Vascular Remodeling Phenotypes in Pulmonary Artery Smooth Muscle Cells Via FAK-Dependent Induction of YAP/TAZ Signaling/ P.B. Dieffenbach, R. Rehman, A.M. Corcoran, C. Mallarino Haeger, A. Coronata, L.E. Fredenburgh, Boston, MA, p.A5051 P1123 Variability in Stretch Amplitude Regulates Vascular Smooth Muscle Cell Phenotype: Implications for Pulmonary Arterial Hypertension/ E. Bartolak-Suki, B. Suki, Boston, MA, p.A5052 P1124 Selective Activation of Estrogen Receptor a Stimulates Pulmonary Vascular Homeostatic Regulator Apelin in Pulmonary Artery Endothelial Cells (PAECs) from Patients with Pulmonary Arterial Hypertension (PAH)/ A.L. Frump, B. Yakubov, M. Albrecht, S.A. Comhair, S.C. Erzurum, D. Tabima Martinez, N.C. Chesler, T. Lahm, Indianapolis, IN, p.A7399 P1125 Right and Left Ventricle Cardiomyocytes Show Distinct Mitochondrial Bioenergetic Profiles/ Q. Nguyen, M. Simon, S. Shiva, Pittsburgh, PA, p.A7400 BASIC • TRANSLATIONAL THEMATIC POSTER SESSION C50 THE PERFECT DRUG: EXPERIMENTAL TREATMENTS OF PAH 9:15 a.m. - 4:15 p.m. KBHCCD Area J (Hall F, Level 2) Viewing: Posters will be on display for entire session. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators. Facilitators : A.A. Desai, MD, Indianapolis, IN K. Tran-Lundmark, MD, PhD, Lund, Sweden P1127 High Dose Ubenimex Interferes with the Efficacy of Sildenafil in Experimental Pulmonary Hypertension/ P. Dahms, A. Tian, P. Zhang, A.B. Tu, X. Jiang, S. Pasupneti, G. Peng, M.R. Nicolls, Palo Alto, CA, p.A5053 P1128 A 5HT1B Antagonist Reverses Pulmonary Hypertension and Right Ventricular Failure and Fibrosis in the Sugen/hypoxic Rat/ C.K. Docherty, S. Fisher, M. Nilsen, D. Hillyard, M.R. MacLean, Glasgow, United Kingdom, p.A5054 P1129 Determination of the Prostanoid Receptor Subtypes Involved in Treprostinil-Induced Relaxation of Rat Pulmonary Arteries with Intact and Denuded Endothelium/ M.R. Corboz, W. Salvail, S. Gagnon, C.E. Laurent, D. Salvail, W.R. Perkins, R.W. Chapman, Bridgewater, NJ, p.A5055 P1130 Extended Release of Inhaled Liposomal Treprostinil Able to Prolong and Improve Reduction of Pulmonary Arterial Pressure in Hypoxia-Induced Pulmonary Hypertension Rats/ P. Kan, K.-J. Chen, C. Han, Taipei, Taiwan, p.A5056 P1131 Comparative Evaluation of Two Different Modalities of Oral Delivery of Macitentan in Experimental Pulmonary Hypertension/ S. Cantoni, M. Cont, F. Pastore, S. Cavalli, F. Dardi, A. Fioni, M. Milioli, G. Villetti, F. Facchinetti, Parma, Italy, p.A5057 Facilitators : K. Suresh, MD, Baltimore, MD J.X.J. Yuan, MD, PhD, La Jolla, CA P1132 Reversal Effect of Lonidamine on Monocrotaline-Induced the Pulmonary and Right Ventricular Remodeling in Rats/ C. Li, G. Lu, M. Liu, J. Su, R. Jiang, R. Zhang, Shanghai, China, p.A5058 P1133 BMP9 Reverses Pulmonary Hypertension in Mice Over-Expressing the Serotonin Transporter/ K. Mair, P. Murray, M. Nilsen, N.W. Morrell, M.R. MacLean, Glasgow, United Kingdom, p.A5059 P1134 Novel PAH Candidate Gene, HINT3, and New Therapeutic Approach of the Ubiquitin Proteasome System in PAH/ A.J. Jang, B.-Y. Kang, Y. Zhao, P. Gallo, R.L. Benza, M. Passineau, Pittsburgh, PA, p.A5060 P1135 Non-Visual Opsins Mediate Light-Dependent Apoptosis of Pulmonary Arterial Smooth Muscle Cells (PASMCs) in a Rat Model of Pulmonary Arterial Hypertension (PAH)/ G. Sikka, X. Yun, V. Tejwani, F.R. D’Alessio, M. Damarla, J. Huetsch, D. Berkowitz, L.A. Shimoda, Baltimore, MD, p.A5061 ATS 2019 • Dallas, TX TUESDAY • MAY 21 263 TUESDAY MORNING