ATS 2019 Virtual Final Program

9:53 Technology to the Rescue: Telemedicine T.G. Buchman, MD, Atlanta, GA 10:07 Forget About the Clock: Just Do It Overnight H.B. Gershengorn, MD, ATSF, Miami, FL 10:21 I Need My Rest: Why Nighttime Isn’t Sleep Time for Patients in the ICU M.A. Pisani, MD, MPH, New Haven, CT 10:35 Improving the Overnight Experience of ICU Patients: Changing the Environment B.B. Kamdar, MD, MBA, MHS, MS, La Jolla, CA 10:49 Improving the Overnight Experience of ICU Patients: Letting Visitors In R. Rosa, MD, MSc, PhD, Porto Alegre, Brazil 11:03 Question and Answer Period M. Hua, MD, MSci, New York, NY TRANSLATIONAL BASIC SCIENCE CORE CME Credits Available: 2 C5 DISCOVERING THE ROLE OF STEM CELL FATE IN LUNG INJURY AND FIBROSIS Assemblies on Allergy, Immunology and Inflammation; Respiratory Cell and Molecular Biology 9:15 a.m. - 11:15 a.m. KBHCCD Ballroom D Two (Level 3) Target Audience Providers of lung health and those with clinical and research responsibilities Objectives At the conclusion of this session, the participant will be able to: • determine the role of mesenchymal stem cells in lung injury and fibrosis; • discuss the molecular mechanisms by which mesenchymal stem cells interact with lung resident cells upon lung tissue injury and repair; • discuss clinical data on mesenchymal stem cells as a potential therapeutic target in acute respiratory distress syndrome (ARDS) and idiopathic pulmonary fibrosis. Recent high impact basic science and clinical papers show the critical role of mesenchymal stem cells in the pathogenesis of acute lung injury and pulmonary fibrosis. Mesenchymal stem cells are emerging as an activator of cellular function to repair damaged lung tissue. The goal of this symposium is to highlight recent exciting data that describes how resident cells and the microenvironment interact with mesenchymal stems to modulate lung injury and fibrosis. Targeting these pathways has the potential to lead to a novel therapeutic approach to treat acute lung tissue injury and fibrosis. Chairing: R.G. Scheraga, MD, Cleveland, OH B.D. Southern, MD, Cleveland, OH B.R. Stripp, PhD, Los Angeles, CA 9:15 Mitophagy and Mesenchymal Stem Cell Survival L.A. Ortiz, MD, Pittsburgh, PA 9:35 Inflammatory Lung Environment Effects on MSC Behaviors D.J. Weiss, MD, PhD, ATSF, Burlington, VT 9:55 Allogeneic Human Mesenchymal Stem Cells for the Treatment of Acute Lung Injury/ARDS M.A. Matthay, MD, San Francisco, CA 10:15 Fibroblast Cell Origin in Idiopathic Pulmonary Fibrosis C.A. Henke, MD, Minneapolis, MN 10:35 Role of Pericytes in Pulmonary Fibrosis L.M. Schnapp, MD, ATSF, Charleston, SC C. Hung, MD, Seattle, WAS 10:55 Stem Cell Therapy for Patients with Idiopathic Pulmonary Fibrosis (IPF) M.K. Glassberg, MD, Miami, FL BASIC • TRANSLATIONAL SCIENTIFIC SYMPOSIUM CME Credits Available: 2 C6 THE FORGOTTEN CELL: RED BLOOD CELLS AS MODULATORS OF IMMUNITY Assemblies on Allergy, Immunology and Inflammation; Critical Care; Respiratory Cell and Molecular Biology 9:15 a.m. - 11:15 a.m. KBHCCD Room C147/C148/C154 (Level 1) Target Audience Basic and translational scientists Objectives At the conclusion of this session, the participant will be able to: • obtain a basic understanding of the immunomodulatory capability of RBCs. Completion of this objective may lead to further research in this rich but understudied field which has relevance to all inflammatory disease states; • understand the role of cell free hemoglobin in both sterile and pathogen induced inflammation; • obtain an understanding of the role of immature RBCs in neonatal host defense. This symposium will provide attendees with a basic understanding of the role of RBCs and their byproducts in regulating the innate immune response and inflammation during sterile and pathogen mediated inflammation. Given the vast number of erythrocytes in circulation and their extraordinary potential to influence immune function, research into the immunologic function of RBCs may yield unique insights into the mechanisms of immune regulation during critical illness. Chairing: N.S. Mangalmurti, MD, Philadelphia, PA M.T. Gladwin, MD, Pittsburgh, PA 9:15 Heightened RBC Disposal Impairs Host Immunity During K. Pneumoniae Sepsis J. Lee, MD, ATSF, Pittsburgh, PA 9:40 Hemolysis as a Mechanism for Human Disease: From Sickle Cell Disease to Precision Transfusion Medicine M.T. Gladwin, MD, Pittsburgh, PA ATS 2019 • Dallas, TX TUESDAY • MAY 21 223 TUESDAY MORNING