ATS 2019 Virtual Final Program

602 Highly NS/2S-Sulfated Heparan Sulfate Fragments Circulating During Sepsis Cause Persistent Cognitive Dysfunction After Sepsis/ J.A. Hippensteel, B.J. Anderson, J.E. Orfila, R.M. Dietz, G. Su, F. Zhang, X. Liu, Y. Yu, X. Han, R. Linhardt, K. Oshima, B. Singer, S. Mcmurtry, N. Meyer, P. Herson, E.P. Schmidt, Aurora, CO, p.A2708 603 Survivors of Murine Pneumosepsis Exhibit Long-Term Behavior Change and Primed Brain IL-1ß Expression/ S.J. Denstaedt, M. Newstead, X. Zeng, T.J. Standiford, B. Singer, Ann Arbor, MI, p.A2709 604 Cigarette Smoking Is Associated with Clinical and Biological Heterogeneity in Patients with the Acute Respiratory Distress Syndrome/ F. Moazed, C.M. Hendrickson, A. Jauregui, K. Vessel, T. Deiss, S. Ke, J. Abbott, H. Zhuo, A.D. Gomez, P. Sinha, K.N. Kangelaris, M.A. Matthay, K. Liu, C.S. Calfee, San Francisco, CA, p.A2710 605 Using Metabolomics to Predict ARDS Mortality/ B.W. Winston, S. Metwaly, M. Banoei, S.J. Donnelly, A. Mourad, H. Vogel, O. Fiehn, Calgary, Canada, p.A2711 606 Mitochondrial DNA in Peripheral Blood Is a Prognostic Biomarker in Sepsis-Induced Acute Respiratory Distress Syndrome Patients/ T. Hernández Beeftink, B. Guillen-Guio, H. Rodriguez-Perez, J.M. Lorenzo-Salazar, A. Corrales, E. Espinosa, A. Muriel, D. Dominguez, A. García de Lorenzo, J.M. Añón, J. Belda, J. Villar, C. Flores, Las Palmas de Gran Canaria, Spain, p.A2712 607 Cleaved RAGE Modifies the Association Between Matrix Metalloproteinase-3 and Mortality in Sepsis/ T.K. Jones, B.J. Anderson, J.P. Reilly, T.G. Dunn, C.A.G. Ittner, M.G.S. Shashaty, R. Feng, J.D. Christie, N. Meyer, Philadelphia, PA, p.A2713 608 Comparison of Alveolar Epithelial Markers of Lung Injury, sRAGE vs SPD, as Markers of Pulmonary and Non-Pulmonary Organ Dysfunction/ M.J. Lim, M. Zinter, K. Gala, L. Chen, M. Guglielmo, A. Bera, L. Huard, A. Schwingshackl, A. Sapru, Los Angeles, CA, p.A2714 609 Plasma Mitochondrial DNA Is Associated with Acute Respiratory Distress Syndrome in Sepsis/ H.E. Faust, J.P. Reilly, B.J. Anderson, N.S. Mangalmurti, P. Zhang, T.G. Dunn, B.A. Weaver, C.A.G. Ittner, J.D. Christie, M.G.S. Shashaty, N. Meyer, Philadelphia, PA, p.A2715 610 Serum Tumor Necrosis Factor Receptor 1 Is Associated with Acute Kidney Injury in Acute Respiratory Distress Syndrome Patients/ P. Huang, Z. Zhu, S. Shen, L. Su, M.M. Wurfel, J.D. Christie, N. Meyer, C.S. Calfee, M.A. Matthay, D.C. Christiani, Boston, MA, p.A2716 611 A Novel Proteomic Approach to Distinguishing Septic Children with Acute Respiratory Distress Syndrome/ N. Yehya, H. Fazeliniah, L. Spruce, G. Lawrence, S.S. Margulies, S. Seeholzer, G.S. Worthen, Philadelphia, PA, p.A2717 612 Assessment of Brain MItochondrial Function in a Septic Murine-Klebsiella Pneumoniae Model/ S.C. Kiel, F. Shah, L.R. Edmunds, B. Chuan, L. Guo, E. Nuzzo, T. Gallego Martin, M. Jurczak, T.D. Girard, C.P. O’Donnell, B.J. McVerry, Pittsburgh, PA, p.A2718 613 Role of miR-466i in Mesenchymal Stem Cell Microvesicles Treating Pneumonia Caused by Drug-Resistant Pseudomonas Aeruginosa/ M. Shi, Y.-G. Zhu, A. Monsel, J.-J. Rouby, J.-M. Qu, Shanghai, China, p.A2719 614 Metabolomic Changes Predict Quality of Life Outcomes 6 Months After Survival of Acute Respiratory Failure/ R.J. Langley, E. Kean, M. Mostellar, M.N. Gillespie, K.S. Harrod, D.C. Files, P.E. Morris, Mobile, AL, p.A2720 615 Programmed Cell Death Ligand 1 Inhibition Improves Survival in a Murine Model of Sepsis Due to Staphylococcus Aureus Pneumonia with a Low- but Not High-Dose Inoculum/ L.M. Busch, Y. Li, Y. Fitz, C. Curran, J. Sun, P.Q. Eichacker, P. Torabi-Parizi, Bethesda, MD, p.A2721 616 Plasma Concentrations of NOX4 Are Predictive of Successful Liberation from Mechanical Ventilation in Critical Ill Patients/ J. Hong, Y. Kim, Y. Hong, Chuncheon, Korea, Republic of, p.A2722 617 Association Between Temperature Trajectory and Cytokine Signatures in Patients with Staphylococcus Aureus Bacteremia/ S. Bhavani, J.A. Greenberg, C. Hrusch, K. Carey, A. Sperling, M.M. Churpek, P.A. Verhoef, Chicago, IL, p.A2723 618 Heme Has Differential Effects in Septic and Non-Septic Mice on Adaptive Immunity/ A. Chmiel, D.J. Yi, S. Mehta, Y. Zeng, J. Unsinger, N. Rateri, R.S. Hotchkiss, K.E. Remy, St. Louis, MO, p.A2724 619 Altered Cellular Metabolism Links the Respiratory Microbiome to Mortality in Critically Ill Patients/ J.A. Howrylak, Z. Ma, K. Nakahira, I.I. Siempos, L. Schultz, J. Broach, A.M.K. Choi, D. Jones, Hershey, PA, p.A2725 620 The Necroptosis Endotype in Neutropenic Critical Illness/ D. Price, C. Oromendia, E. Sanchez, K.C. Ma, E. Schenck, K. Nakahira, M.E. Choi, R.M. Baron, L.E. Fredenburgh, A. Higuera, M. Pinilla Vera, J.W. Huh, J.Y. Lee, G.Y. Suh, I.I. Siempos, A.M.K. Choi, New York, NY, p.A2726 621 Hyperoncotic Albumin Attenuates Brain Damage Compared to Saline and Iso Oncotic Albumin in Experimental Focal Ischemic Stroke/ R.D.S. Mendes, G. Martins, M.V. de Oliveira, N.D.N. Rocha, C.D.S. Samary, R. Fonseca, A. Fernandes, P. Pelosi, P. Pimentel, F.F. Cruz, P.R.M. Rocco, P.L. Silva, Rio de Janeiro, Brazil, p.A2727 622 Transcriptomic Response to Lung Collapse During Experimental Single-Lung Ventilation/ C. Zeng, G.C. Motta Ribeiro, T. Hinoshita, M. Lessa Ribeiro Neto, T. Winkler, M.F. Vidal Melo, Boston, MA, p.A2728 623 Pharmacologic Inhibition of Janus Kinase 1 and 2 Worsens Survival in Murine Sepsis/ S. Conway, C.E. Hoptay, K. Harmon, A. Opoka, R.J. Freishtat, H.R. Wong, Washington, DC, p.A2729 624 Thyroid Hormone Regulates Immune Response of Macrophages in Sepsis/ D. Zhang, H. Lee, Y. Jin, Boston, MA, p.A2730 625 A Large-Scale Trans-Ancestry GWAS-Meta Analysis of the Genetic Architecture of ARDS Susceptibility/ M. Du, M.M. Wurfel, N.J. Meyer, J.D. Christie, M. Gonzalez-Garay, L. Su, J.G.N. Garcia, F. Chen, D.C. Christiani, Boston, MA, p.A2731 ATS 2019 • Dallas, TX 136 MONDAY • MAY 20