ATS 2019 Virtual Final Program

10:45 Synergistic Effect of Nitric Oxide with Antibiotics Against Mycobacterium Abscessus in Vitro/ T. Chau, J. da Silva, A. Ghaffari, A. Zelazny, K.N. Olivier, Bethesda, MD, p.A2656 11:00 Mesenchymal Stem Cell Therapy and Chronic Non-Tuberculous Mycobacterium Infection/ T.L. Bonfield, L. Auster, V. Ragavapuram, D. Fletcher, M. Sutton, R. Somoza, J. Kurtzberg, M.K. Glassberg Csete, A.I. Caplan, Cleveland, OH, p.A2657 BASIC • CLINICAL • TRANSLATIONAL MINI SYMPOSIUM B20 LUNG TRANSPLANTATION: MODELS AND MECHANISMS 9:15 a.m. - 11:15 a.m. KBHCCD Ballroom A Three (Level 2) Chairing: J.F. McDyer, MD, Pittsburgh, PA D.E. Byers, MD, PhD, ATSF, St. Louis, MO C.M. Shaver, MD, PhD, Nashville, TN Oral Presentations 9:15 Distinct Cell Populations Drive Lymphocytic Bronchiolitis After Lung Transplantation/ N.F. Smirnova, W. Ren, M.P. Steele, A.L. Gray, O. Eickelberg, Aurora, CO, p.A2658 9:30 Gli1 Labeled Mesenchymal Cells Are the Primary Contributor to Peribronchial Fibrosis in Murine Models of Chronic Lung Allograft Dysfunction/ R. Braeuer, N. Walker, K. Misumi, D.S. Wheeler, R. Vittal, M.P. Combs, V.N. Lama, Ann Arbor, MI, p.A2659 9:45 Monocyte-Dependent Interleukin-6 Trans-Signaling Induces Lung Allograft Fibrosis/ D.S. Wheeler, M.P. Combs, N.M. Walker, R. Braeuer, K. Misumi, R. Vittal, V.N. Lama, Ann Arbor, MI, p.A2660 10:00 An Orthotopic Ferret Single Lung Transplant Model Develops Both Obliterative Bronchiolitis and Restrictive Allograft Syndrome/ T.J. Lynch,A.M. Swatek, B.A. Ahlers, L. Brooks, D. Meyerholz, J.F. Englhardt, K.R. Parekh, Iowa City, IA, p.A2661 10:15 Induction of the Classical Complement Pathway and Properidin in Chronic Lung Allograft Dysfunction/ R. Vittal, R.R. Braeuer, K. Misumi, N.M. Walker, M.P. Combs, D.S. Wheeler, V.N. Lama, Ann Arbor, MI, p.A2662 10:30 Pulmonary Lymphatics Regulate Immune Cell Trafficking and Lung Injury/ H. Outtz Reed, M.L. Kahn, Philadelphia, PA, p.A2663 10:45 T-bet Expression in T Cells Is Critical for Costimulation Blockade-Induced Allograft Acceptance in Mouse Orthotopic Lung Transplant/ E.A. Lendermon, X. Wang, M. Brown, I. Popescu, A. Hoji, J.F. McDyer, Pittsburgh, PA, p.A2664 11:00 The Role of Iron-Induced Macrophage Dysregulation in Aspergillus Fumigatus Invasion in Airway Transplantation/ E.I. Matthaiou, O.M. Manouvakhova, M. Sinha, A.B. Tu, K.V. Clemons, D.A. Stevens, M.R. Nicolls, J.L. Hsu, Palo Alto, CA, p.A2665 BASIC • CLINICAL • TRANSLATIONAL RAPID: RAPID ABSTRACT POSTER DISCUSSION SESSION B21 SEVERE ASTHMA: CLINICAL AND MECHANISTIC STUDIES 9:15 a.m. - 11:15 a.m. KBHCCD Room D222-D224 (Level 2) Abstract Summaries 9:15-9:45 Viewing/Discussion 9:45-11:15 Chairing: S.B. Khatri, MD, MS, Cleveland, OH M. Kraft, MD, ATSF, Tucson, AZ A. Ray, PhD, Pittsburgh, PA 501 Dupilumab Improved Asthma Control and Health-Related Quality of Life in Patients with Oral-Corticosteroid-Dependent Severe Asthma in the Phase 3 LIBERTY ASTHMA VENTURE Study/ L.B. Ford, K.F. Rabe, R.N. Wolfe, S. Quirce, M.S. Rice, P. Rowe, Y. Lu, S. Kamat, N. Amin, N.M.H. Graham, A. Teper, A. Khan, Bellevue, NE, p.A2666 502 Dupilumab Reduces Severe Exacerbations and Improves Lung Function in Late-Onset, Uncontrolled, Moderate-to-Severe Asthma Patients Enrolled in the LIBERTY ASTHMA QUEST Study/ N.A. Hanania, E.D. Bateman, M. Castro, I.D. Pavord, A. Papi, J.M. FitzGerald, J.F. Maspero, C. Katelaris, D. Singh, M.S. Rice, P. Rowe, Y. Lu, N. Amin, H.W. Staudinger, N.M.H. Graham, A. Teper, Houston, TX, p.A2667 503 Dupilumab Improved Lung Function in Patients with Uncontrolled, Moderate-to-Severe Asthma Despite Exacerbation Events During the LIBERTY ASTHMA QUEST Study/ K.F. Rabe, M. Castro, S.E. Wenzel, J. Corren, I.D. Pavord, C. Katelaris, Y. Tohda, M.S. Rice, Y. Lu, P. Rowe, H.W. Staudinger, N. Amin, B. Akinlade, N.M.H. Graham, A. Teper, Grosshansdorf and Kiel, Germany, p.A2668 504 Dupilumab Improved Morning and Evening Daily Asthma Symptoms in Patients with Oral-Corticosteroid-Dependent Severe Asthma in the Phase 3 LIBERTY ASTHMA VENTURE Study/ L. Sher, K.F. Rabe, R.N. Wolfe, S. Quirce, M.S. Rice, P. Rowe, Y. Lu, S. Kamat, N. Amin, N.M.H. Graham, A. Teper, A. Khan, Rolling Hills Estates, CA, p.A2669 505 Efficacy and Safety of Dupilumab for the Treatment of Uncontrolled Asthma: A Meta-Analysis of Randomized Clinical Trials/ X.-F. Xiong, D.-Y. Cheng, Chengdu, China, p.A2670 506 Characterisation of Exacerbations of Severe Eosinophilic Asthma on Mepolizumab Compared to Placebo/ R. Shrimanker, O. Keene, D.J. Bratton, S. Yancey, L. Heaney, I.D. Pavord, Oxford, United Kingdom, p.A2671 507 Efficacy of Mepolizumab in Patients with Severe Eosinophilic Asthma and Concomitant Aspirin-Exacerbated Respiratory Disease: Meta-Analysis of Two Phase III Trials/ T. Laidlaw, F.C. Albers, D.J. Bratton, E. Bradford, S.G. Smith, J.-P. Llanos, C. Taillé, N.L. Lugogo, Boston, MA, p.A2672 ATS 2019 • Dallas, TX MONDAY • MAY 20 133 MONDAY MORNING