ATS 2021 will feature presentations of original research from accepted abstracts. Mini Symposia and Thematic Poster Sessions are abstract based sessions.
Please use the form below to browse scientific abstracts and case reports accepted for ATS 2021. Abstracts presented at the ATS 2021 will be published in the Online Abstract Issue of the American Journal of Respiratory and Critical Care Medicine, Volume 203, May 3, 2021.
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Gender-Specific Differences in COPD Symptoms and Their Impact for the Diagnosis of Cardiac Comorbidities: Results from COSYCONET
Session Title
TP39 - TP039 COPD COMORBIDITIES
Abstract
A2228 - Gender-Specific Differences in COPD Symptoms and Their Impact for the Diagnosis of Cardiac Comorbidities: Results from COSYCONET
Author Block: F. C. Trudzinski1, C. Kellerer2, R. Jörres3, P. Alter4, J. I. Lutter5, F. Trinkmann6, F. J. Herth7, M. Frankenberger8, H. Watz9, C. Vogelmeier10, H. Kauczor11, T. Welte12, J. Behr13, R. Bals14, K. Kahnert15; 11Department of Pneumology and Critical Care Medicine, Thoraxklinik, Heidelberg, Germany, 2School of Medicine, Institute of General Practice and Health Services Research, Technical University of Munich, Munich, Germany, 3Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig Maximilians University (LMU), Munich, Germany, 4Dept of Medicine, Pulm & Critical Care Med, Philipps University of Marburg (UMR), Marburg, Germany, 5Institute of Health Economics and Health Care Management, Helmholtz Zentrum München GmbH - German Research Center for Environmental Health, Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany, Munich, Germany, 6Pneumology and Critical Care Medicine, Thoraxklinik Heidelberg, Heidelberg, Germany, 7Thoraxklinik University of Heidelberg, Heidelberg, Germany, 8CPC Comprehensive Pneumology Center, Helmholtz Zentrum München, Ludwig-Maximilians University Munich and Asklepios Hospital Gauting, Munich, Germany, 9Pneumologisches Forschungsinstitut a, Großhansdorf, Germany, 10Philipps Universitat Marburg, Marburg, Germany, 11Department of Diagnostic & Interventional Radiology, University Hospital of Heidelberg, German Center for Lung Research (DZL), Heidelberg, Germany, Heidelberg, Germany, 12Dept. of Respiratory Medicine, Medizinische Hochschule Hannover, Hannover, Germany, 13Internal Medicine V, University of Munich, Comprehensive Pneumology Ctr., Munchen, Germany, 14Internal Medicine V - Pulmonology, Saarland University Hopsital, Homburg, Germany, 15Department of Internal Medicine V,, LMU Munich, Comprehensive Pneumology Center, German Center for Lung Research (DZL), Munich, Germany.
Background: In chronic obstructive pulmonary disease (COPD), gender-specific differences in the level of symptoms and prevalence of comorbidities have been described. We studied whether the relationship between these characteristics was dependent on gender and whether they had different diagnostic value for cardiac comorbidities. Study Design and Methods: The analysis was based on 2046 patients (795 women; 38.8% ) of GOLD grades 1-4 from the COSYCONET COPD cohort. Assessments comprised the determination of clinical history and comorbidities, lung function, the COPD Assessment Test (CAT) and the modified Medical Research Council dyspnea scale (mMRC). Using multivariate regression analyses, potential gender differences in the relationship between symptoms, especially single CAT items, and the pattern of comorbidities and functional alterations were determined. In addition, we performed logistic regression analyses with age, BMI, smoking status, mMRC, CAT items, and z-scores of FEV1 and FEV1/FVC as predictors, to reveal the relationship to cardiac disease (defined as myocardial infarction, heart failure, or coronary artery disease) separately in men and women. Results: Most functional parameters and comorbidities, as well as CAT items 1 (cough), 2 (phlegm) and 5 (activities), showed significant (p<0.05) different values in men and women. Beyond this, the relationship between functional parameters and comorbidities versus symptoms showed gender-specific differences, especially for single CAT items. In men, logistic regression identified CAT item 8 (energy), mMRC, smoking status, BMI, age and spirometric lung function being related to cardiac disease. In women, only age was of predictive value for this disease. Conclusion: Gender-specific differences in COPD comprised not only differences in the level or prevalence of symptoms, comorbidities and functional alterations but also differences in their mutual relationships. This was reflected in different sets of predictors for cardiac disease. Our findings give hints how diagnostic information might be used differently in men and women.
Author Block: F. C. Trudzinski1, C. Kellerer2, R. Jörres3, P. Alter4, J. I. Lutter5, F. Trinkmann6, F. J. Herth7, M. Frankenberger8, H. Watz9, C. Vogelmeier10, H. Kauczor11, T. Welte12, J. Behr13, R. Bals14, K. Kahnert15; 11Department of Pneumology and Critical Care Medicine, Thoraxklinik, Heidelberg, Germany, 2School of Medicine, Institute of General Practice and Health Services Research, Technical University of Munich, Munich, Germany, 3Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig Maximilians University (LMU), Munich, Germany, 4Dept of Medicine, Pulm & Critical Care Med, Philipps University of Marburg (UMR), Marburg, Germany, 5Institute of Health Economics and Health Care Management, Helmholtz Zentrum München GmbH - German Research Center for Environmental Health, Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany, Munich, Germany, 6Pneumology and Critical Care Medicine, Thoraxklinik Heidelberg, Heidelberg, Germany, 7Thoraxklinik University of Heidelberg, Heidelberg, Germany, 8CPC Comprehensive Pneumology Center, Helmholtz Zentrum München, Ludwig-Maximilians University Munich and Asklepios Hospital Gauting, Munich, Germany, 9Pneumologisches Forschungsinstitut a, Großhansdorf, Germany, 10Philipps Universitat Marburg, Marburg, Germany, 11Department of Diagnostic & Interventional Radiology, University Hospital of Heidelberg, German Center for Lung Research (DZL), Heidelberg, Germany, Heidelberg, Germany, 12Dept. of Respiratory Medicine, Medizinische Hochschule Hannover, Hannover, Germany, 13Internal Medicine V, University of Munich, Comprehensive Pneumology Ctr., Munchen, Germany, 14Internal Medicine V - Pulmonology, Saarland University Hopsital, Homburg, Germany, 15Department of Internal Medicine V,, LMU Munich, Comprehensive Pneumology Center, German Center for Lung Research (DZL), Munich, Germany.
Background: In chronic obstructive pulmonary disease (COPD), gender-specific differences in the level of symptoms and prevalence of comorbidities have been described. We studied whether the relationship between these characteristics was dependent on gender and whether they had different diagnostic value for cardiac comorbidities. Study Design and Methods: The analysis was based on 2046 patients (795 women; 38.8% ) of GOLD grades 1-4 from the COSYCONET COPD cohort. Assessments comprised the determination of clinical history and comorbidities, lung function, the COPD Assessment Test (CAT) and the modified Medical Research Council dyspnea scale (mMRC). Using multivariate regression analyses, potential gender differences in the relationship between symptoms, especially single CAT items, and the pattern of comorbidities and functional alterations were determined. In addition, we performed logistic regression analyses with age, BMI, smoking status, mMRC, CAT items, and z-scores of FEV1 and FEV1/FVC as predictors, to reveal the relationship to cardiac disease (defined as myocardial infarction, heart failure, or coronary artery disease) separately in men and women. Results: Most functional parameters and comorbidities, as well as CAT items 1 (cough), 2 (phlegm) and 5 (activities), showed significant (p<0.05) different values in men and women. Beyond this, the relationship between functional parameters and comorbidities versus symptoms showed gender-specific differences, especially for single CAT items. In men, logistic regression identified CAT item 8 (energy), mMRC, smoking status, BMI, age and spirometric lung function being related to cardiac disease. In women, only age was of predictive value for this disease. Conclusion: Gender-specific differences in COPD comprised not only differences in the level or prevalence of symptoms, comorbidities and functional alterations but also differences in their mutual relationships. This was reflected in different sets of predictors for cardiac disease. Our findings give hints how diagnostic information might be used differently in men and women.
