ATS 2021 will feature presentations of original research from accepted abstracts. Mini Symposia and Thematic Poster Sessions are abstract based sessions.
Please use the form below to browse scientific abstracts and case reports accepted for ATS 2021. Abstracts presented at the ATS 2021 will be published in the Online Abstract Issue of the American Journal of Respiratory and Critical Care Medicine, Volume 203, May 3, 2021.
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Outcome of Surgical and Endoscopic Lung Volume Reduction with Valves in Patients with Severe Lung Emphysema: Preliminary Results from the National Lung Emphysema Registry (LE-R) in Germany
Session Title
TP40 - TP040 COPD CLINICAL TRIALS AND THERAPIES
Abstract
A2261 - Outcome of Surgical and Endoscopic Lung Volume Reduction with Valves in Patients with Severe Lung Emphysema: Preliminary Results from the National Lung Emphysema Registry (LE-R) in Germany
Author Block: P. Lenga1, C. Grah2, C. Ruwwe-Glösenkamp1, J. Saccomanno1, S. Eggeling3, J. Pfannschmidt4, S. Gläser5, S. Kurz6, G. Lesschber7, J. Rückert8, B. Schmidt9, P. Schneider10, R. A. Gebhardt11, A. Gebhardt12, B. Becke13, O. Schega13, A. Holland14, A. Kirschbaum15, S. Eisenmann16, M. Krüger17, R. Hübner1; 1Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Pneumology, Hospital Havelhoehe, Berlin, Germany, 3Thoracic Surgery, Vivantes Netzwerk für Gesundheit, Berlin, Germany, 4Thoracic Surgery, Helios Klinikum Emil von Behring, Berlin, Germany, 5Pulmonary Medicine and Infectious Diseases, Vivantes-Klinikum Neukölln, Berlin, Germany, 6Respiratory Medicine, ELK Berlin Chest Hospital, Berlin, Germany, 7Thoracic Surgery, ELK Berlin Chest Hospital, Berlin, Germany, 8Thoracic Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany, 9Respiratory Medicine, DRK Kliniken Berlin Mitte, Berlin, Germany, 10Thoracic Surgery, DRK Kliniken Berlin Mitte, Berlin, Germany, 11Praxis Dr Rainer Gebhardt, Berlin, Germany, 12Internal Medicine and Respiratory Medicine, , Helios Hospital Emil von Behring, Berlin, Germany, 13Respiratory Medicine, Johanniter-Krankenhaus, Treuenbrietzen, Germany, 14Respiratory Medicine, Uniklinikum Marburg, Marburg, Germany, 15Thoracic Surgery, Uniklinikum Marburg, Marburg, Germany, 16Respiratory Medicine, Universitätsklinik Halle, Halle, Germany, 17Thoracic Surgery, Martha-Maria Clinic, Halle, Germany.
IntroductionChronic obstructive pulmonary disease (COPD) is a debilitating disease and is projected to rank fifth worldwide in terms of burden of disease and in terms of mortality. Surgical lung volume reduction (LVRS) has been suggested to produce favorable outcomes in patients with severe emphysema. However, as clinical evidence on endoscopic lung volume reduction (ELVR) with valves (EBV) accumulates, these techniques seem promising since they might also lead to significant ameliorations of both lung function parameters and quality of life. Notwithstanding, a systematical analysis of treatment approaches is still missing and reports on treatment outcome per treatment technique are predominantly of anecdotal character. Using data from the LE-R, our main goal is to describe treatment outcomes of the applied strategies over time. MethodsThe LE-R is a national multicenter prospective open label clinical study collecting exclusively data on patients with severe emphysema treated at specialized centers all over Germany. The patients were followed up after 3 months, and the lung function (FEV1, RV, VC, DLCO) as well as the clinical status and the quality of life, measured with the 6-MWT, and mMRC were documented. Results212 cases were treated with endobronchial valves and 129 cases had a surgical procedure. The overall mean age was 65.0 y (SD 7.7) and there was a predominance of the male gender (63.6%). Table 1 depicts differences of lung function and quality of life between the groups at baseline and 3-months follow up.ConclusionsOur first results suggest that both surgical and endoscopic lung volume reduction with valves are reliable and efficacious treatment strategies in patients with severe emphysema. These findings might serve as a basis for the development of future research focusing on treatment types that should be applied to the specific patients’ subgroups.
Author Block: P. Lenga1, C. Grah2, C. Ruwwe-Glösenkamp1, J. Saccomanno1, S. Eggeling3, J. Pfannschmidt4, S. Gläser5, S. Kurz6, G. Lesschber7, J. Rückert8, B. Schmidt9, P. Schneider10, R. A. Gebhardt11, A. Gebhardt12, B. Becke13, O. Schega13, A. Holland14, A. Kirschbaum15, S. Eisenmann16, M. Krüger17, R. Hübner1; 1Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Pneumology, Hospital Havelhoehe, Berlin, Germany, 3Thoracic Surgery, Vivantes Netzwerk für Gesundheit, Berlin, Germany, 4Thoracic Surgery, Helios Klinikum Emil von Behring, Berlin, Germany, 5Pulmonary Medicine and Infectious Diseases, Vivantes-Klinikum Neukölln, Berlin, Germany, 6Respiratory Medicine, ELK Berlin Chest Hospital, Berlin, Germany, 7Thoracic Surgery, ELK Berlin Chest Hospital, Berlin, Germany, 8Thoracic Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany, 9Respiratory Medicine, DRK Kliniken Berlin Mitte, Berlin, Germany, 10Thoracic Surgery, DRK Kliniken Berlin Mitte, Berlin, Germany, 11Praxis Dr Rainer Gebhardt, Berlin, Germany, 12Internal Medicine and Respiratory Medicine, , Helios Hospital Emil von Behring, Berlin, Germany, 13Respiratory Medicine, Johanniter-Krankenhaus, Treuenbrietzen, Germany, 14Respiratory Medicine, Uniklinikum Marburg, Marburg, Germany, 15Thoracic Surgery, Uniklinikum Marburg, Marburg, Germany, 16Respiratory Medicine, Universitätsklinik Halle, Halle, Germany, 17Thoracic Surgery, Martha-Maria Clinic, Halle, Germany.
IntroductionChronic obstructive pulmonary disease (COPD) is a debilitating disease and is projected to rank fifth worldwide in terms of burden of disease and in terms of mortality. Surgical lung volume reduction (LVRS) has been suggested to produce favorable outcomes in patients with severe emphysema. However, as clinical evidence on endoscopic lung volume reduction (ELVR) with valves (EBV) accumulates, these techniques seem promising since they might also lead to significant ameliorations of both lung function parameters and quality of life. Notwithstanding, a systematical analysis of treatment approaches is still missing and reports on treatment outcome per treatment technique are predominantly of anecdotal character. Using data from the LE-R, our main goal is to describe treatment outcomes of the applied strategies over time. MethodsThe LE-R is a national multicenter prospective open label clinical study collecting exclusively data on patients with severe emphysema treated at specialized centers all over Germany. The patients were followed up after 3 months, and the lung function (FEV1, RV, VC, DLCO) as well as the clinical status and the quality of life, measured with the 6-MWT, and mMRC were documented. Results212 cases were treated with endobronchial valves and 129 cases had a surgical procedure. The overall mean age was 65.0 y (SD 7.7) and there was a predominance of the male gender (63.6%). Table 1 depicts differences of lung function and quality of life between the groups at baseline and 3-months follow up.ConclusionsOur first results suggest that both surgical and endoscopic lung volume reduction with valves are reliable and efficacious treatment strategies in patients with severe emphysema. These findings might serve as a basis for the development of future research focusing on treatment types that should be applied to the specific patients’ subgroups.
