ATS 2021 will feature presentations of original research from accepted abstracts. Mini Symposia and Thematic Poster Sessions are abstract based sessions.
Please use the form below to browse scientific abstracts and case reports accepted for ATS 2021. Abstracts presented at the ATS 2021 will be published in the Online Abstract Issue of the American Journal of Respiratory and Critical Care Medicine, Volume 203, May 3, 2021.
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Impact of the UK Lockdown on Early COPD
Session Title
TP22 - TP022 IMPACT OF SARS-COV-2 INFECTION IN PULMONARY MEDICINE: TRANSMISSION PREVENTION, IMPACT ON CHRONIC RESPIRATORY DISEASE, AND TREATMENT
Abstract
A1768 - Impact of the UK Lockdown on Early COPD
Author Block: G. C. Donaldson1, A. I. Ritchie1, F. McLean1, B. King2, K. Yip3, A. S. Beech4, A. Bikov5, A. R. Jenkins6, A. Deans7, C. E. Bolton8, P. M. Calverley9, G. Choudhury7, L. McGarvey10, E. Sapey11, J. Vestbo4, J. A. Wedzicha12; 1COPD group, Imperial College London, London, United Kingdom, 2Belfast Health and Social Care Trust, Belfast, United Kingdom, 3Institute of Inflammation and Ageing, Birmingham, United Kingdom, 4University of Manchester, Manchester, United Kingdom, 5Manchester University NHS Foundation Trust, Manchester, United Kingdom, 6Division of Respiratory Medicine, University of Nottingham, Nottingham, United Kingdom, 7University of Edinburgh, Edinburgh, United Kingdom, 8Nottingham Respiratory Research Unit, The University of Nottingham, Nottingham, United Kingdom, 9Univ Hospital Aintree, Univ of Liverpool, Liverpool, United Kingdom, 10Queen's University Belfast, Belfast, United Kingdom, 11Univ of Birmingham, Birmingham, United Kingdom, 12Imperial College London, London, United Kingdom.
INTRODUCTION: Public health measures to reduce the transmission of COVID-19 have required various changes in life-style, including loss or risk to employment and social isolation. We wished to assess how these measured effected 30-45 year old smokers at risk of COPD participating in the BLF Early COPD cohort study
METHODS: At enrolment, participants were aged 30-45 years, tobacco smokers with >10 pack-year smoking history, FEV1=>80% predicted and a BMI < 35kg/m2. Participants were seen face-to-face in clinic pre-COVID. During lock-down, they were posted questionnaires and contacted by telephone. The last clinic visit took place on the 12 March 2020, remote visits took place between 16 April and 28 Sep. 260 individuals at six sites (25 Belfast, 38 Birmingham, 25 Edinburgh, 101 London, 27 Manchester and 44 Nottingham) were asked about smoking habits. The MRC chronic bronchitis questionnaire, COPD Assessment test (CAT), Leicester cough questionnaire, Hospital Anxiety and Depression questionnaire were completed in writing by the participant and returned by post or photographed and returned by email. At enrolment, the post-BD FEV1 was 3.81 (SD 0.8) litres, 101% (11) of GLI predicted. Comparisons were made by paired t-tests and chi-squared tests.
RESULTS: Level of anxiety increased from 6.74 (SD 4.4) to 7.37 (SD 4.7, n=233; p=0.010) during lock-down; depression scores increased from 4.30 (3.9) to 5.14 (SD 4.1; n=233; p<0.001). Anxiety increased in 78/233 and depression in 89/233 participants by 2 or more units, 2 units is considered the minimally important (MCID) in bronchiectasis, COPD and ILD (Wynne, 2020) Figure 1 shows that during lock-down, the proportion of participants not smoking increased from 31/259 (12.0%) to 62/259 (23.9%; p<0.001). In those who continued to smoke, cigarettes per day (p=0.59) and rolling tobacco consumption (g/week) (p=0.92) were unchanged. Participants reported less chronic bronchitis defined as “do you bring up phlegm like this on most days (or nights) as much as three months each year”, fell from 83/260 (31.9%) participants to 74/259 (28.6%; p<0.001). CAT scores fell from 10.5 (SD 6.4) to 9.6 (SD 6.3; n=233; p=0.007) and total cough score improved from 18.7 (SD 2.7) to 19.1 (2.6; n=204; p=0.007).
CONCLUSIONS: Despite increased anxiety and depression, participants quit smoking and those that continued to smoke, did not smoke more. Respiratory symptoms of chronic bronchitis, cough and CAT scores improved.
REFERENCES:Wynne SC, et al. Chron Respir Dis. 2020 Jan-Dec;17:1479973120933292. doi: 10.1177/1479973120933292.
Author Block: G. C. Donaldson1, A. I. Ritchie1, F. McLean1, B. King2, K. Yip3, A. S. Beech4, A. Bikov5, A. R. Jenkins6, A. Deans7, C. E. Bolton8, P. M. Calverley9, G. Choudhury7, L. McGarvey10, E. Sapey11, J. Vestbo4, J. A. Wedzicha12; 1COPD group, Imperial College London, London, United Kingdom, 2Belfast Health and Social Care Trust, Belfast, United Kingdom, 3Institute of Inflammation and Ageing, Birmingham, United Kingdom, 4University of Manchester, Manchester, United Kingdom, 5Manchester University NHS Foundation Trust, Manchester, United Kingdom, 6Division of Respiratory Medicine, University of Nottingham, Nottingham, United Kingdom, 7University of Edinburgh, Edinburgh, United Kingdom, 8Nottingham Respiratory Research Unit, The University of Nottingham, Nottingham, United Kingdom, 9Univ Hospital Aintree, Univ of Liverpool, Liverpool, United Kingdom, 10Queen's University Belfast, Belfast, United Kingdom, 11Univ of Birmingham, Birmingham, United Kingdom, 12Imperial College London, London, United Kingdom.
INTRODUCTION: Public health measures to reduce the transmission of COVID-19 have required various changes in life-style, including loss or risk to employment and social isolation. We wished to assess how these measured effected 30-45 year old smokers at risk of COPD participating in the BLF Early COPD cohort study
METHODS: At enrolment, participants were aged 30-45 years, tobacco smokers with >10 pack-year smoking history, FEV1=>80% predicted and a BMI < 35kg/m2. Participants were seen face-to-face in clinic pre-COVID. During lock-down, they were posted questionnaires and contacted by telephone. The last clinic visit took place on the 12 March 2020, remote visits took place between 16 April and 28 Sep. 260 individuals at six sites (25 Belfast, 38 Birmingham, 25 Edinburgh, 101 London, 27 Manchester and 44 Nottingham) were asked about smoking habits. The MRC chronic bronchitis questionnaire, COPD Assessment test (CAT), Leicester cough questionnaire, Hospital Anxiety and Depression questionnaire were completed in writing by the participant and returned by post or photographed and returned by email. At enrolment, the post-BD FEV1 was 3.81 (SD 0.8) litres, 101% (11) of GLI predicted. Comparisons were made by paired t-tests and chi-squared tests.
RESULTS: Level of anxiety increased from 6.74 (SD 4.4) to 7.37 (SD 4.7, n=233; p=0.010) during lock-down; depression scores increased from 4.30 (3.9) to 5.14 (SD 4.1; n=233; p<0.001). Anxiety increased in 78/233 and depression in 89/233 participants by 2 or more units, 2 units is considered the minimally important (MCID) in bronchiectasis, COPD and ILD (Wynne, 2020) Figure 1 shows that during lock-down, the proportion of participants not smoking increased from 31/259 (12.0%) to 62/259 (23.9%; p<0.001). In those who continued to smoke, cigarettes per day (p=0.59) and rolling tobacco consumption (g/week) (p=0.92) were unchanged. Participants reported less chronic bronchitis defined as “do you bring up phlegm like this on most days (or nights) as much as three months each year”, fell from 83/260 (31.9%) participants to 74/259 (28.6%; p<0.001). CAT scores fell from 10.5 (SD 6.4) to 9.6 (SD 6.3; n=233; p=0.007) and total cough score improved from 18.7 (SD 2.7) to 19.1 (2.6; n=204; p=0.007).
CONCLUSIONS: Despite increased anxiety and depression, participants quit smoking and those that continued to smoke, did not smoke more. Respiratory symptoms of chronic bronchitis, cough and CAT scores improved.
REFERENCES:Wynne SC, et al. Chron Respir Dis. 2020 Jan-Dec;17:1479973120933292. doi: 10.1177/1479973120933292.
