Browse ATS 2021 Abstracts

HomeProgram ▶ Browse ATS 2021 Abstracts

ATS 2021 will feature presentations of original research from accepted abstracts. Mini Symposia and Thematic Poster Sessions are abstract based sessions.

Please use the form below to browse scientific abstracts and case reports accepted for ATS 2021. Abstracts presented at the ATS 2021 will be published in the Online Abstract Issue of the American Journal of Respiratory and Critical Care Medicine, Volume 203, May 3, 2021.

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Prevalence and Characteristics of Self-Reported Lymphoma in US Sarcoidosis Patients

Session Title
A1823 - Prevalence and Characteristics of Self-Reported Lymphoma in US Sarcoidosis Patients
Author Block: B. N. Alzghoul1, Y. Zayed1, B. Alzghoul2, A. Obeidat3, A. Shilbayeh3, A. Naser4, M. Buchanan5, T. Al-Hakim6, B. Mehrad7, D. C. Patel8; 1Pulmonary,Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, United States, 2Internal Medicine, ; University of Kentucky, Lexington, KY, United States, 3Medicine, Jordan University of Science and Technology Faculty of Medicine, Irbid, Jordan, 4Medicine, Hashemite University Faculty of Medicine; Zarqa, Jordan, Zarqa, Jordan, 5Foundation for Sarcoidosis Research, Chicago, IL, United States, 6Research, Foundation for Sarcoidosis Research, Chicago, IL, United States, 7Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, FL, United States, 8Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, United States.
Rationale: Sarcoidosis is thought to be associated with increased risk of lymphoproliferative disorders but little is known about the association. Therefore, we sought to determine the clinical characteristics of sarcoidosis patients who also reported developing lymphoma after their sarcoidosis diagnosis and determine differences with patients who do not develop lymphoma. Methods: We conducted a national registry-based study investigating 3,560 respondents to the Foundation for Sarcoidosis Research Sarcoidosis Advanced Registry for Cures Questionnaire (FSR-SARC) including patient surveys completed between June 2014 and August 2019. The primary objective of the study was to find the prevalence of self-reported lymphoma in patients with sarcoidosis. Secondary objectives were to determine the demographic, clinical characteristics and organ involvement of the sarcoidosis patients who reported lymphoma. Because only a minority of patients reported having lymphoma and to avoid skewed comparison with the rest of the patients due to large difference in number of patients with and without lymphoma, we randomly selected a computer-generated control sample of sarcoidosis patients who did not report having lymphoma with a 2:1 ratio as a comparison group. Results: Among 3,560 patients with sarcoidosis, 43 (1.2%) reported developing lymphoma sometime after their sarcoidosis diagnosis. Patients with lymphoma were more likely to be diagnosed with sarcoidosis at a younger age (39 ± 14 vs 45 ± 13 years, P=0.008), were more likely to be African Americans (OR, 95% CI; 3.9 (1.6-9.6, P=0.002) and have low annual income (2.2, 1.04-4.8, P=0.038). Among all the organs reported to be involved with sarcoidosis, lymphoma patients were more likely to have cutaneous manifestations (2.9; 1.1-7.3, P=0.023). Patients with lymphoma were also more likely to have sarcoidosis-related hospitalizations (2.2; 1.04-4.8, P=0.038), hypertension (2.6; 1.1-5.9, P=0.021), chronic fatigue (2.6; 1.1-5.9, P=0.021), chronic pain syndrome (4; 1.7-9.8, P=0.001) and depression (2.5; 1.2-5.6, P=0.019). This reflected on more employment- based disability (P=0.027) and disease-related job termination (P=0.014) in the lymphoma group (Table 1). Conclusion: To our knowledge, this is the largest study to assess the prevalence and characteristics of lymphoma in patients with sarcoidosis. The prevalence of lymphoma reported in this registry is higher than what is reported in the general population which further supports the possible increased risk of lymphoma in sarcoidosis. Diagnosis of sarcoidosis at a younger age, African American race and cutaneous sarcoidosis were associated with lymphoma. Sarcoidosis patients who developed lymphoma reported higher disease burden and more non-organ specific manifestations.